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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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FUS

Introduction

Fusion (involved in t(12;16) in malignant liposarcoma), also known as FUS, is a human gene.[1]

References

References

  1. ↑ “Entrez Gene: FUS fusion (involved in t(12;16) in malignant liposarcoma)”.
Further reading

Further reading

  • Kaplowitz N, Ji C (2007). “Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum”. J. Gastroenterol. Hepatol. 21 Suppl 3: S7–9. doi:10.1111/j.1440-1746.2006.04581.x. PMID 16958678.
  • Eneroth M, Mandahl N, Heim S; et al. (1990). “Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2”. Cancer Genet. Cytogenet. 48 (1): 101–7. PMID 2372777.
  • Rabbitts TH, Forster A, Larson R, Nathan P (1993). “Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma”. Nat. Genet. 4 (2): 175–80. doi:10.1038/ng0693-175. PMID 7503811.
  • Panagopoulos I, Mandahl N, Ron D; et al. (1995). “Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation”. Cancer Res. 54 (24): 6500–3. PMID 7987849.
  • Ichikawa H, Shimizu K, Hayashi Y, Ohki M (1994). “An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation”. Cancer Res. 54 (11): 2865–8. PMID 8187069.
  • Crozat A, Aman P, Mandahl N, Ron D (1993). “Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma”. Nature. 363 (6430): 640–4. doi:10.1038/363640a0. PMID 8510758.
  • Aman P, Panagopoulos I, Lassen C; et al. (1997). “Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS”. Genomics. 37 (1): 1–8. doi:10.1006/geno.1996.0513. PMID 8921363.
  • Zinszner H, Sok J, Immanuel D; et al. (1997). “TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling”. J. Cell. Sci. 110 ( Pt 15): 1741–50. PMID 9264461.
  • Powers CA, Mathur M, Raaka BM; et al. (1998). “TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors”. Mol. Endocrinol. 12 (1): 4–18. PMID 9440806.
  • Hallier M, Lerga A, Barnache S; et al. (1998). “The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS”. J. Biol. Chem. 273 (9): 4838–42. PMID 9478924.
  • Zhang D, Paley AJ, Childs G (1998). “The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription”. J. Biol. Chem. 273 (29): 18086–91. PMID 9660765.
  • Yang L, Embree LJ, Tsai S, Hickstein DD (1998). “Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing”. J. Biol. Chem. 273 (43): 27761–4. PMID 9774382.
  • Morohoshi F, Ootsuka Y, Arai K; et al. (1998). “Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes”. Gene. 221 (2): 191–8. PMID 9795213.
  • Bertrand P, Akhmedov AT, Delacote F; et al. (1999). “Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation”. Oncogene. 18 (31): 4515–21. doi:10.1038/sj.onc.1203048. PMID 10442642.
  • Baechtold H, Kuroda M, Sok J; et al. (1999). “Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation”. J. Biol. Chem. 274 (48): 34337–42. PMID 10567410.
  • Yang L, Embree LJ, Hickstein DD (2000). “TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins”. Mol. Cell. Biol. 20 (10): 3345–54. PMID 10779324.
  • Husi H, Ward MA, Choudhary JS; et al. (2000). “Proteomic analysis of NMDA receptor-adhesion protein signaling complexes”. Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
  • Uranishi H, Tetsuka T, Yamashita M; et al. (2001). “Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator”. J. Biol. Chem. 276 (16): 13395–401. doi:10.1074/jbc.M011176200. PMID 11278855.
  • Saunders LR, Perkins DJ, Balachandran S; et al. (2001). “Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR”. J. Biol. Chem. 276 (34): 32300–12. doi:10.1074/jbc.M104207200. PMID 11438536.
  • Lee J, Bedford MT (2002). “PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays”. EMBO Rep. 3 (3): 268–73. doi:10.1093/embo-reports/kvf052. PMID 11850402.

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