Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

Familial adenomatous polyposis differential diagnosis

Introduction

Overview

Overview

Familial adenomatous polyposis must be differentiated from other diseases that cause multiple polyps, such as Peutz–Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, Carney syndrome, and hereditary non–polyposis colon cancer (Lynch syndrome).

Differentiating familial adenomatous polyposis from other Diseases

Differentiating familial adenomatous polyposis from other Diseases

Familial adenomatous polyposis must be differentiated from other diseases that cause multiple polyps including:[1][2][3][4][5]

Diseases History and Symptoms Physical Examination Laboratory Findings Other Findings
Abdominal Pain Rectal Bleeding Fatigue Abdominal Tenderness Hyperpigmentation Anemia Gene(s) Gastrointestinal Tumors Cancers
Familial Adenomatous Polyposis + + + +/– – +
Peutz–Jeghers syndrome + + + + + +
Juvenile Polyposis Syndrome + + – – –
Cowden Syndrome – – – – –
Carney Syndrome – – – – –
Hereditary Non–Polyposis Colon Cancer – + + +/– – +
References

References

  1. ↑ Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean L, Stephens K, Amemiya A, Jasperson KW, Patel SG, Ahnen DJ. “APC-Associated Polyposis Conditions”. PMID 20301519. Vancouver style error: initials (help)
  2. ↑ Beech D, Pontius A, Muni N, Long WP (2001). “Familial adenomatous polyposis: a case report and review of the literature”. J Natl Med Assoc. 93 (6): 208–13. PMC 2594024. PMID 11446392.
  3. ↑ Half, Elizabeth; Bercovich, Dani; Rozen, Paul (2009). “Familial adenomatous polyposis”. Orphanet Journal of Rare Diseases. 4 (1): 22. doi:10.1186/1750-1172-4-22. ISSN 1750-1172.
  4. ↑ Nieuwenhuis, M.H.; Vasen, H.F.A. (2007). “Correlations between mutation site in APC and phenotype of familial adenomatous polyposis (FAP): A review of the literature”. Critical Reviews in Oncology/Hematology. 61 (2): 153–161. doi:10.1016/j.critrevonc.2006.07.004. ISSN 1040-8428.
  5. ↑ King, John E.; Dozois, Roger R.; Lindor, Noralane M.; Ahlquist, David A. (2000). “Care of Patients and Their Families With Familial Adenomatous Polyposis”. Mayo Clinic Proceedings. 75 (1): 57–67. doi:10.4065/75.1.57. ISSN 0025-6196.

​​ ​

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]