Familial adenomatous polyposis screening
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2], Mohamad Alkateb, MBBCh [3]
Overview
Overview
Screening for familial adenomatous polyposis by genetic testing and/or colonoscopy is recommended among patients with history of multiple colonic adenomas and family history of familial adenomatous polyposis.
Screening
Screening
Screening for familial adenomatous polyposis is recommended in the following patients:[1][2]
- Positive family history of FAP in the first degree relative
- It must be started at the age of the youngest family member’s polyps or symptoms
Screening for familial adenomatous polyposis for individuals at high risk may be done by:
- Sigmoidoscopy every 2 years beginning at age of 10 years
- Colonoscopy every year following finding an adenoma
- Endoscopy concomitant with colonoscopy
- Side viewing endoscopy beginning at age 15 years to evaluate ampulla
- Genetic testing[3]
References
References
- ↑ King, John E.; Dozois, Roger R.; Lindor, Noralane M.; Ahlquist, David A. (2000). “Care of Patients and Their Families With Familial Adenomatous Polyposis”. Mayo Clinic Proceedings. 75 (1): 57–67. doi:10.4065/75.1.57. ISSN 0025-6196.
- ↑ Kennedy, Raelene D.; Potter, D. Dean; Moir, Christopher R.; El-Youssef, Mounif (2014). “The natural history of familial adenomatous polyposis syndrome: A 24year review of a single center experience in screening, diagnosis, and outcomes”. Journal of Pediatric Surgery. 49 (1): 82–86. doi:10.1016/j.jpedsurg.2013.09.033. ISSN 0022-3468.
- ↑ Roy, Hemant K.; Khandekar, Janardan D. (2012). “APC Gene Testing for Familial Adenomatosis Polyposis”. JAMA. 308 (5): 514. doi:10.1001/jama.2012.9516. ISSN 0098-7484.
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