Familial adenomatous polyposis secondary prevention

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

All patients with familial adenomatous polyposis will develop colorectal cancer. For secondary prevention of colorectal cancer total colectomy must be done. Effective tests for the secondary prevention of other complications and associated conditions include annual pouchoscopy following surgery and annual physical examination and ultrasound.

Secondary Prevention

Effective measures for the secondary prevention of colorectal cancer include:^[1]
- Total colectomy
Effective tests for the secondary prevention of complications and associated conditions include:^[2]

Condition	Test	Frequency
Anastomotic polyp recurrence after ileal pouch anal anastomosis (IPAA)	Pouchoscopy	Every year
Hepatoblastoma	Alpha-fetoprotein and abdominal ultrasound	Every year from birth until the age of 10 years
Soft tissue or bone lesions	Physical examination	Every year
Thyroid conditions	Ultrasound	Every year

References

↑ Kennedy, Raelene D.; Potter, D. Dean; Moir, Christopher R.; El-Youssef, Mounif (2014). “The natural history of familial adenomatous polyposis syndrome: A 24year review of a single center experience in screening, diagnosis, and outcomes”. Journal of Pediatric Surgery. 49 (1): 82–86. doi:10.1016/j.jpedsurg.2013.09.033. ISSN 0022-3468.
↑ Half, Elizabeth; Bercovich, Dani; Rozen, Paul (2009). “Familial adenomatous polyposis”. Orphanet Journal of Rare Diseases. 4 (1): 22. doi:10.1186/1750-1172-4-22. ISSN 1750-1172.

Overview