Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Fanconi anemia risk factors
Introduction
Overview
Overview
The major risk factor for Fanconi anemia is genetic inheritance. It is inherited in an autosomal recessive pattern.
Risk factors
Risk factors
The major risk factor for Fanconi anemia is genetic inheritance. It is inherited in an autosomal recessive pattern, meaning that both parents must harbor the gene mutation to have an affected child. There are no other particular risk factors for Fanconi anemia. This is a genetic disorder that is caused by a mutation in genes involved in DNA damage response. Patients with Fanconi anemia are more susceptible to malignancy such as acute myeloid leukemia, and a risk factor for development of malignancies includes exposure to radiation and carcinogens.[1]
References
References
- ↑ Romick-Rosendale LE, Lui VW, Grandis JR, Wells SI (2013). “The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma”. Mutat Res. 743-744: 78–88. doi:10.1016/j.mrfmmm.2013.01.001. PMC 3661751. PMID 23333482.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]