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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Fasciolosis medical therapy

Introduction

Overview

Overview

Medical therapy

Medical therapy

Anthelmintics

For high efficacy and safety, triclabendazole (Egaten®) in dose 10-12 mg/kg is drug of choice in human fasciolosis.[1] No drug alternatives are available for humans. On the other hand, nitazoxanide were successfully used in human fasciolosis treatment in Mexico.[2] Bithionol is another drug of choice used for treatment of fasciola hepatica.[3]

Antimicrobial Regimen

  • Preferred regimen: Triclabendazole 10 mg/kg PO one dose[4]
  • Note: Two-dose (double-dose) triclabendazole therapy can be given to patients who have severe or heavy Fasciola infections (many parasites) or who did not respond to single-dose therapy.
  • Alternative regimen: Nitazoxanide 500mg PO bid for 7 days
References

References

  1. ↑ Savioli, L., Chistulo, L., Montresor, A., 1999. New opportunities for the control of fascioliasis. Bull. WHO 77, 300.
  2. ↑ Rossignol, J.F., Abaza, H., Friedman, H., 1998. Successful treatment of human fascioliasis with nitazoxanide. Trans. Roy. Soc. Trop. Med. Hyg. 92, 103–104.
  3. ↑ Ramachandran, A., 2000. Pharmacology Recall.
  4. ↑ “Parasites – Fascioliasis”.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]