Fasciolosis medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Medical therapy

Anthelmintics

For high efficacy and safety, triclabendazole (Egaten®) in dose 10-12 mg/kg is drug of choice in human fasciolosis.^[1] No drug alternatives are available for humans. On the other hand, nitazoxanide were successfully used in human fasciolosis treatment in Mexico.^[2] Bithionol is another drug of choice used for treatment of fasciola hepatica.^[3]

Antimicrobial Regimen

Fasciola hepatica Return to Top

Preferred regimen: Triclabendazole 10 mg/kg PO one dose^[4]
Note: Two-dose (double-dose) triclabendazole therapy can be given to patients who have severe or heavy Fasciola infections (many parasites) or who did not respond to single-dose therapy.
Alternative regimen: Nitazoxanide 500mg PO bid for 7 days

References

↑ Savioli, L., Chistulo, L., Montresor, A., 1999. New opportunities for the control of fascioliasis. Bull. WHO 77, 300.
↑ Rossignol, J.F., Abaza, H., Friedman, H., 1998. Successful treatment of human fascioliasis with nitazoxanide. Trans. Roy. Soc. Trop. Med. Hyg. 92, 103–104.
↑ Ramachandran, A., 2000. Pharmacology Recall.
↑ “Parasites – Fascioliasis”.

[1] Savioli, L., Chistulo, L., Montresor, A., 1999. New opportunities for the control of fascioliasis. Bull. WHO 77, 300.

[2] Rossignol, J.F., Abaza, H., Friedman, H., 1998. Successful treatment of human fascioliasis with nitazoxanide. Trans. Roy. Soc. Trop. Med. Hyg. 92, 103–104.

[3] Ramachandran, A., 2000. Pharmacology Recall.

[4] “Parasites – Fascioliasis”.

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