Fatty liver natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Natural History

Complications

Up to 10% of cirrhotic alcoholic FLD will develop hepatocellular carcinoma. Overall incidence of liver cancer in non-alcoholic FLD has not been assessed yet but the association is well established.^[1]

A retrospective cohort study concluded that liver failure is the main cause of morbidity and mortality in NASH-associated cirrhosis. The prognosis is either similar or less severe than HCV-cirrhosis.^[2]

http://nafldscore.com/

Prognosis

Prognosis can be determined by:

FIB-4
Liver stiffness measurement
- Vibration-controlled elastography (VCTE), Fibroscan

- Magnetic resonance elastography (MRE)

References

↑ Qian Y, Fan JG (2005). “Obesity, fatty liver and liver cancer”. HBPD INT. 4 (2): 173–7. PMID 15908310.
↑ Hui JM, Kench JG, Chitturi S; et al. (2003). “Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C”. Hepatology. 38 (2): 420–7. doi:10.1053/jhep.2003.50320. PMID 12883486.

[1] Qian Y, Fan JG (2005). “Obesity, fatty liver and liver cancer”. HBPD INT. 4 (2): 173–7. PMID 15908310.

[pmid12883486-2] Hui JM, Kench JG, Chitturi S; et al. (2003). “Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C”. Hepatology. 38 (2): 420–7. doi:10.1053/jhep.2003.50320. PMID 12883486.

[1]

[2]

Fatty liver natural history, complications and prognosis

Natural History

Complications

Prognosis

References

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