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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Fever of unknown origin overview

Introduction

Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; FUO; PUO; pyrexia of unknown origin

Overview

Overview

Fever of unknown origin (FUO) was formally defined for the first time by Petersdorf and Beeson: β€œfever above 38.3Β° C (100.9Β° F) on several occasions, persisting without diagnosis for at least three weeks in spite of at least one week’s investigation in hospital.ΚΊ[1]

Durack and Street made four different categories of fever of unknown origin in 1991:

  1. Classic FUO
  2. Nosocomial FUO
  3. Neutropenic FUO
  4. HIV related FUO[2]
References

References

  1. ↑ Auwaerter, Paul G; Wright, William F (2020). “Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma”. Open Forum Infectious Diseases. 7 (5). doi:10.1093/ofid/ofaa132. ISSNΒ 2328-8957.
  2. ↑ Auwaerter, Paul G; Wright, William F (2020). “Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma”. Open Forum Infectious Diseases. 7 (5). doi:10.1093/ofid/ofaa132. ISSNΒ 2328-8957.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]