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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Fibroadenoma classification

Introduction

Overview

Overview

Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, giant fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.

Classification

Classification

  • Fibroadenoma may be classified according to microscopic histopathological analysis into five subtypes, which include:[1]
  • Juvenile fibroadenoma
  • Complex fibroadenoma
  • Giant fibroadenoma
  • Myxoid fibroadenoma
  • Cellular fibroadenoma
  • The table below differentiates between the main subtypes of fibrodenoma according to microscopic histopathological analysis:[1][2][3]
Fibroadenoma Subtype Description
Juvenile fibroadenoma
  • Commonly found in ages 10 to 18 years.
  • Stromal and epithelial hyperplasia
  • Tapering, thin micropapillae (gynecomastoid hyperplasia)
  • Mitoses is absent
  • Occurs mostly in African Americans
  • Rapid growth
  • Associated with skin ulcerations and prominent veins
  • Referred to as a giant fibroadenoma when it is >5cm, >500g, or replaces more than 80% of the breast
Complex fibroadenoma
  • Excessive proliferation of epithelial cells
  • Apocrine metaplasia
  • Cysts > 3 mm
  • Calcification
  • Sclerosing adenosis
Giant fibroadenoma
  • >5cm in diameter
  • High stromal cellularity
  • Rapid growth
  • Usually seen in pregnant or lactating women
Myxoid fibroadenoma
  • Myxoid stroma
Cellular fibroadenoma
  • Relatively high cellular component
  • Increased mitotic rate
  • Absence of calcification and sclerosing adenosis
  • Sometimes referred to as juvenile fibroadenoma
References

References

  1. ↑ 1.0 1.1 Cerrato F, Labow BI (2013). “Diagnosis and management of fibroadenomas in the adolescent breast”. Semin Plast Surg. 27 (1): 23–5. doi:10.1055/s-0033-1343992. PMC 3706050. PMID 24872735.
  2. ↑ Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A; et al. (2017). “A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review”. Int J Surg Case Rep. 41: 427–430. doi:10.1016/j.ijscr.2017.11.026. PMC 5702868. PMID 29546008.
  3. ↑ Greenberg R, Skornick Y, Kaplan O (1998). “Management of breast fibroadenomas”. J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe, M.D. [2] Haytham Allaham, M.D. [3]