Fibroadenoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe, M.D. [2] Haytham Allaham, M.D. [3]

Overview

Fibroadenoma may be classified according to microscopic histopathological analysis into four subtypes, which include juvenile fibroadenoma, complex fibroadenoma, giant fibroadenoma, myxoid fibroadenoma, and cellular fibroadenoma.

Classification

Fibroadenoma may be classified according to microscopic histopathological analysis into five subtypes, which include:^[1]

Juvenile fibroadenoma
Complex fibroadenoma
Giant fibroadenoma
Myxoid fibroadenoma
Cellular fibroadenoma

The table below differentiates between the main subtypes of fibrodenoma according to microscopic histopathological analysis:^[1]^[2]^[3]


Fibroadenoma Subtype	Description

Juvenile fibroadenoma	Commonly found in ages 10 to 18 years. Stromal and epithelial hyperplasia Tapering, thin micropapillae (gynecomastoid hyperplasia) Mitoses is absent Occurs mostly in African Americans Rapid growth Associated with skin ulcerations and prominent veins Referred to as a giant fibroadenoma when it is >5cm, >500g, or replaces more than 80% of the breast
Complex fibroadenoma	Excessive proliferation of epithelial cells Apocrine metaplasia Cysts > 3 mm Calcification Sclerosing adenosis
Giant fibroadenoma	>5cm in diameter High stromal cellularity Rapid growth Usually seen in pregnant or lactating women
Myxoid fibroadenoma	Myxoid stroma
Cellular fibroadenoma	Relatively high cellular component Increased mitotic rate Absence of calcification and sclerosing adenosis Sometimes referred to as juvenile fibroadenoma

References

↑ ^1.0 ^1.1 Cerrato F, Labow BI (2013). “Diagnosis and management of fibroadenomas in the adolescent breast”. Semin Plast Surg. 27 (1): 23–5. doi:10.1055/s-0033-1343992. PMC 3706050. PMID 24872735.
↑ Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A; et al. (2017). “A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review”. Int J Surg Case Rep. 41: 427–430. doi:10.1016/j.ijscr.2017.11.026. PMC 5702868. PMID 29546008.
↑ Greenberg R, Skornick Y, Kaplan O (1998). “Management of breast fibroadenomas”. J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.

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[pmid24872735-1] 1.0 ^1.1 Cerrato F, Labow BI (2013). “Diagnosis and management of fibroadenomas in the adolescent breast”. Semin Plast Surg. 27 (1): 23–5. doi:10.1055/s-0033-1343992. PMC 3706050. PMID 24872735.

[pmid29546008-2] Giannos A, Stavrou S, Gkali C, Chra E, Marinopoulos S, Chalazonitis A; et al. (2017). “A prepubertal giant juvenile fibroadenoma in a 12-year-old girl: Case report and brief literature review”. Int J Surg Case Rep. 41: 427–430. doi:10.1016/j.ijscr.2017.11.026. PMC 5702868. PMID 29546008.

[pmid9754521-3] Greenberg R, Skornick Y, Kaplan O (1998). “Management of breast fibroadenomas”. J Gen Intern Med. 13 (9): 640–5. PMC 1497021. PMID 9754521.

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Fibroadenoma classification

Overview

Classification

References

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