Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Fibromuscular dysplasia causes
Introduction
Overview
Overview
The cause of fibromuscular dysplasia has not been identified.
Cause
Cause
The cause of fibromuscular dysplasia has not been identified. A variety of factors have been implicated. These include:
- Genetic predisposition with a reported autosomal mode of inheritance in some families[1][2]
- Hormonal influence, given the predominance in women of childbearing age
- Mechanical factors such as stretching of smooth muscle cells and trauma to the blood vessel wall
- Ischemia of the blood vessel wall due to fibrotic occlusion of the vasavasorum
References
References
- ↑ Perdu J, Boutouyrie P, Bourgain C, et al. Inheritance of arterial lesions in renal 􀉹bromuscular dysplasia. J Hum Hypertens 2007; 21:393
- ↑ Ganesh SK, Morissette R, Xu Z, et al. Clinical and biochemical pro􀉹les suggest 􀉹bromuscular dysplasia is a systemic disease with altered TGF-β expression and connective tissue features. FASEB J 2014; 28:3313
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohsen Basiri M.D.