Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Fixed dose combination (antiretroviral)
Introduction
Fixed dose combinations of antiretrovirals are multiple antiretroviral drugs combined into a single pill, which helps reduce pill burden. They may combine different classes of antiretrovirals or contain only a single class. Licensed fixed dose combinations are shown in the table below.
| Brand Name | Drug Names (INN) | Date of FDA Approval | Company |
|---|---|---|---|
| Combivir® | zidovudine + lamivudine | September 26, 1997 | GlaxoSmithKline |
| Trizivir® | abacavir + zidovudine + lamivudine | November 15, 2000 | GlaxoSmithKline |
| Kaletra® | lopinavir + ritonavir | September 15, 2000 | Abbott Laboratories |
| Epzicom® (in USA) Kivexa® (in Europe) |
abacavir + lamivudine | August 2, 2004 | GlaxoSmithKline |
| Truvada® | emtricitabine + tenofovir | August 2, 2004 | Gilead Sciences |
| Atripla® | efavirenz + emtricitabine + tenofovir | July 12, 2006 | Gilead Sciences and Bristol-Myers Squibb |