Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Focal segmental glomerulosclerosis historical perspective
Introduction
Overview
Overview
Focal segmental glomerulosclerosis (FSGS) was discovered by Theodor Fahr, a German pathologist, in 1925, and he referred to it as “lipoid nephrosis with degeneration“, showing a clear association to minimal change disease. In 1957, FSGS was then described by Dr. Arnold Rich, a pathologist at Johns Hopkins University.
Historical Perspective
Historical Perspective
Discovery
- Focal segmental glomerulosclerosis (FSGS) was first discovered by Theodor Fahr, a German pathologist, in 1925.[1]
- He referred to it as “lipoid nephrosis with degeneration“, showing a clear association to minimal change disease.[2]
- In 1957, FSGS was then described by Dr. Arnold Rich, a pathologist at Johns Hopkins University.[3]
- In 1970, Jacob Churg and colleagues finally classified FSGS as a unique renal glomerulopathy in the ” Pathology of the Nephrotic Syndrome in Children: Report for the International Study of Kidney Disease in Children” in view of its clinical and pathological features, and its steroid–resistance in comparison to minimal change disease.[4]
References
References
- ↑ Fahr, T (1925). Pathologische anatomie des morbus brightii. In: Fahr T, Gruber GB, Koch M, et al. eds. Harnorgane Männliche Geschlechtsorgane. Vienna: Springer. pp. 156–472.
- ↑ Fahr, T (1925). Pathologische anatomie des morbus brightii. In: Fahr T, Gruber GB, Koch M, et al. eds. Harnorgane Männliche Geschlechtsorgane. Vienna: Springer. pp. 156–472.
- ↑ RICH AR (1957). “A hitherto undescribed vulnerability of the juxtamedullary glomeruli in lipoid nephrosis”. Bull Johns Hopkins Hosp. 100 (4): 173–86. PMID 13426687.
- ↑ Churg J, Habib R, White RH (1970). “Pathology of the nephrotic syndrome in children: a report for the International Study of Kidney Disease in Children”. Lancet. 760 (1): 1299–302. PMID 4193942.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [3], Manpreet Kaur, MD [4], Olufunmilola Olubukola M.D.[5]