Focal segmental glomerulosclerosis historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [3], Manpreet Kaur, MD [4], Olufunmilola Olubukola M.D.[5]

Overview

Focal segmental glomerulosclerosis (FSGS) was discovered by Theodor Fahr, a German pathologist, in 1925, and he referred to it as “lipoid nephrosis with degeneration“, showing a clear association to minimal change disease. In 1957, FSGS was then described by Dr. Arnold Rich, a pathologist at Johns Hopkins University.

Historical Perspective

Focal segmental glomerulosclerosis (FSGS) was first discovered by Theodor Fahr, a German pathologist, in 1925.^[1]
He referred to it as “lipoid nephrosis with degeneration“, showing a clear association to minimal change disease.^[2]
In 1957, FSGS was then described by Dr. Arnold Rich, a pathologist at Johns Hopkins University.^[3]
In 1970, Jacob Churg and colleagues finally classified FSGS as a unique renal glomerulopathy in the ” Pathology of the Nephrotic Syndrome in Children: Report for the International Study of Kidney Disease in Children” in view of its clinical and pathological features, and its steroid–resistance in comparison to minimal change disease.^[4]

References

↑ Fahr, T (1925). Pathologische anatomie des morbus brightii. In: Fahr T, Gruber GB, Koch M, et al. eds. Harnorgane Männliche Geschlechtsorgane. Vienna: Springer. pp. 156–472.
↑ Fahr, T (1925). Pathologische anatomie des morbus brightii. In: Fahr T, Gruber GB, Koch M, et al. eds. Harnorgane Männliche Geschlechtsorgane. Vienna: Springer. pp. 156–472.
↑ RICH AR (1957). “A hitherto undescribed vulnerability of the juxtamedullary glomeruli in lipoid nephrosis”. Bull Johns Hopkins Hosp. 100 (4): 173–86. PMID 13426687.
↑ Churg J, Habib R, White RH (1970). “Pathology of the nephrotic syndrome in children: a report for the International Study of Kidney Disease in Children”. Lancet. 760 (1): 1299–302. PMID 4193942.

Overview