Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Focal segmental glomerulosclerosis history and symptoms
Introduction
Overview
Overview
History and Symptoms
History and Symptoms
The hallmark of focal segmental glomerulosclerosis is nephrotic-range proteinuria.[1]
History
Patients with focal segmental glomerulosclerosis may have a positive history of:[2][3][4]
- Positive family history of FSGN
- Heroin abuse
- Chronic viral infections such as hepatitis B
- Medications such as bisphosphonates, sunitinib, and interferon
Common Symptoms
Common symptoms of focal segmental glomerulosclerosis include:[5][6]
- Proteinuria
- Hematuria
- Anasarca
- Headache and blurry vision which is suggestive of high blood pressure
Less Common Symptoms
Less common symptoms of focal segmental glomerulosclerosis include
- Fatigue
- Malaise
- Symptoms of chronic renal failure such as anuria, edema
References
References
- ↑ Rydel JJ, Korbet SM, Borok RZ, Schwartz MM (1995). “Focal segmental glomerular sclerosis in adults: presentation, course, and response to treatment”. Am J Kidney Dis. 25 (4): 534–42. PMID 7702047.
- ↑ D’Agati VD, Kaskel FJ, Falk RJ (December 2011). “Focal segmental glomerulosclerosis”. N. Engl. J. Med. 365 (25): 2398–411. doi:10.1056/NEJMra1106556. PMID 22187987.
- ↑ Dijkman HB, Weening JJ, Smeets B, Verrijp KC, van Kuppevelt TH, Assmann KK, Steenbergen EJ, Wetzels JF (July 2006). “Proliferating cells in HIV and pamidronate-associated collapsing focal segmental glomerulosclerosis are parietal epithelial cells”. Kidney Int. 70 (2): 338–44. doi:10.1038/sj.ki.5001574. PMID 16761013.
- ↑ {{cite journal |vauthors=Markowitz GS, Nasr SH, Stokes MB, D’Agati VD |title=Treatment with IFN-{alpha}, -{beta}, or -{gamma} is associated with collapsing focal segmental glomerulosclerosis |journal=Clin J Am Soc Nephrol |volume=5 |issue=4 |pages=607–15 |date=April 2010 |pmid=20203164 |pmc=2849683 |doi=10.2215/CJN.07311009 |url=}}
- ↑ Choy BY, Chan TM, Lai KN (November 2006). “Recurrent glomerulonephritis after kidney transplantation”. Am. J. Transplant. 6 (11): 2535–42. doi:10.1111/j.1600-6143.2006.01502.x. PMID 16939521.
- ↑ Baum MA, Ho M, Stablein D, Alexander SR (December 2002). “Outcome of renal transplantation in adolescents with focal segmental glomerulosclerosis”. Pediatr Transplant. 6 (6): 488–92. PMID 12453201.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Manpreet Kaur, MD [2]