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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Focal segmental glomerulosclerosis natural history, complications and prognosis

Introduction

Overview

Overview

Natural History, Complications, and Prognosis

Natural History, Complications, and Prognosis

Natural History

  • The symptoms of focal segmental glomerulosclerosis usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.
  • The symptoms of (disease name) typically develop ___ years after exposure to ___.
  • If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].

Complications

Common complications of focal segmental glomerulosclerosis include:[1]

  • End stage renal disease
  • Malnutrition
  • Infections
  • Nephrotic syndrome

Prognosis

  • There are several clinical and pathological features which predict the outcome.
  • Factors which are associated with worse prognosis of focal segmental glomerulosclerosis include:[2][3]:
    • Black race
    • Increased degrees of proteinuria
    • renal insufficiency
    • Increased severity of interstitial fibrosis
    • Tubular atrophy in biopsy specimens
References

References

  1. ↑ Korbet SM (1999). “Clinical picture and outcome of primary focal segmental glomerulosclerosis”. Nephrol Dial Transplant. 14 Suppl 3: 68–73. PMID 10382985.
  2. ↑ “Focal Segmental Glomerulosclerosis in Nephrotic Adults: Presentation, Prognosis, and Response to Therapy of the Histologic Variants”.
  3. ↑ Sohal, DS; Prabhakar, SS (November 02, 2011). “Focal segmental glomerulosclerosis” (PDF). Interchopen. InTech. Retrieved 3 December 2013. Check date values in: |date= (help)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]