Follicular lymphoma classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

According to the World Health Organization (WHO), follicular lymphoma may be classified into 3 subtypes: low-grade follicular lymphoma, high-grade follicular lymphoma, and diffuse large B cell lymphoma. Three variants of follicular lymphoma include pediatric follicular lymphoma, primary intestinal follicular lymphoma, and other extranodal follicular lymphoma.

Classification

1- Morphological Classification

The World Health Organization (WHO) classifies follicular lymphoma as follows:^[1]^[2]

Grades 1 and 2 also known as low-grade follicular lymphoma
Grade 3A as high-grade follicular lymphoma
Grade 3B as diffuse large B cell lymphoma

2- Variants of Follicular Lymphoma

Follicular lymphoma has 3 variants that include the following:^[3]^[4]

A. Pediatric follicular lymphoma

Involves cervical lymph nodes, other peripheral lymph nodes, or Waldeyer’s ring
Patients typically have early-stage disease
Lacks bcl-2 protein expression and t(14;18)

B. Primary intestinal follicular lymphoma

Occurs most commonly in the small intestine, and frequently involves the duodenum.

Duodenal follicular lymphoma

Found in the second portion of the duodenum
Present as multiple polyps
Diagnosis is most often an incidental finding
Most patients have localized disease
Prognosis is excellent even without treatment

C. Other extranodal follicular lymphomas

Usually have localized extranodal disease.
Systemic relapses are rare.
Testicular follicular lymphoma are reported with increased frequency in children, but also are reported in adults.

References

↑ “Follicular Lymphomas”. Retrieved 2008-07-26.
↑ Anderson T, Chabner BA, Young RC, Berard CW, Garvin AJ, Simon RM; et al. (1982). “Malignant lymphoma. 1. The histology and staging of 473 patients at the National Cancer Institute”. Cancer. 50 (12): 2699–707. PMID 7139563.
↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov
↑ Kojima M, Yamanaka S, Yoshida T, Shimizu K, Murayama K, Ohno Y; et al. (2006). “Histological variety of floral variant of follicular lymphoma”. APMIS. 114 (9): 626–32. doi:10.1111/j.1600-0463.2006.apm_424.x. PMID 16948815.

[urlFollicular_Lymphomas-1] “Follicular Lymphomas”. Retrieved 2008-07-26.

[pmid7139563-2] Anderson T, Chabner BA, Young RC, Berard CW, Garvin AJ, Simon RM; et al. (1982). “Malignant lymphoma. 1. The histology and staging of 473 patients at the National Cancer Institute”. Cancer. 50 (12): 2699–707. PMID 7139563.

[”seer”-3] National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov

[pmid16948815-4] Kojima M, Yamanaka S, Yoshida T, Shimizu K, Murayama K, Ohno Y; et al. (2006). “Histological variety of floral variant of follicular lymphoma”. APMIS. 114 (9): 626–32. doi:10.1111/j.1600-0463.2006.apm_424.x. PMID 16948815.

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