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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Follicular lymphoma classification

Introduction

Overview

Overview

According to the World Health Organization (WHO), follicular lymphoma may be classified into 3 subtypes: low-grade follicular lymphoma, high-grade follicular lymphoma, and diffuse large B cell lymphoma. Three variants of follicular lymphoma include pediatric follicular lymphoma, primary intestinal follicular lymphoma, and other extranodal follicular lymphoma.

Classification

Classification

1- Morphological Classification

The World Health Organization (WHO) classifies follicular lymphoma as follows:[1][2]

  • Grades 1 and 2 also known as low-grade follicular lymphoma
  • Grade 3A as high-grade follicular lymphoma
  • Grade 3B as diffuse large B cell lymphoma

2- Variants of Follicular Lymphoma

Follicular lymphoma has 3 variants that include the following:[3][4]

A. Pediatric follicular lymphoma

B. Primary intestinal follicular lymphoma

  • Found in the second portion of the duodenum
  • Present as multiple polyps
  • Diagnosis is most often an incidental finding
  • Most patients have localized disease
  • Prognosis is excellent even without treatment

C. Other extranodal follicular lymphomas

  • Usually have localized extranodal disease.
  • Systemic relapses are rare.
  • Testicular follicular lymphoma are reported with increased frequency in children, but also are reported in adults.
References

References

  1. ↑ “Follicular Lymphomas”. Retrieved 2008-07-26.
  2. ↑ Anderson T, Chabner BA, Young RC, Berard CW, Garvin AJ, Simon RM; et al. (1982). “Malignant lymphoma. 1. The histology and staging of 473 patients at the National Cancer Institute”. Cancer. 50 (12): 2699–707. PMID 7139563.
  3. ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov
  4. ↑ Kojima M, Yamanaka S, Yoshida T, Shimizu K, Murayama K, Ohno Y; et al. (2006). “Histological variety of floral variant of follicular lymphoma”. APMIS. 114 (9): 626–32. doi:10.1111/j.1600-0463.2006.apm_424.x. PMID 16948815.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]