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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Foreign-body giant cell

Introduction

Histopathologic image of aspiration pneumonia in an elderly patient with debilitating neurologic illness. Note foreign-body giant cell reaction. Autopsy case. H & E stain.
Overview

Overview

A foreign-body giant cell is a collection of fused macrophages (giant cell) which are generated in response to the presence of a large foreign body. This is particularly evident with implants that cause the body chronic inflammation and foreign body response. [1]

The nuclei are arranged in a disorganized manner.[2] This is in contrast to a Langhans giant cell, where the nuclei are arranged on the border.

Additional images

Additional images

  • Foreign-body giant cell reaction to a suture. H&E stain.
    Foreign-body giant cell reaction to a suture. H&E stain.
References

References

  1. ↑ Foreign+Body+Giant+Cell at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ↑ “Inflammation”.

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