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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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Friedreich's ataxia medical therapy

Introduction

Overview

Overview

Pharmacologic medical therapy is recommended among patients with Friedreich’s ataxia but their affect in decrease the symptoms of Friedreich’s ataxia is not significant. Pharmacologic medical therapies for Friedreich’s ataxia include Physostigmine, Riluzole and Amantadine. The rationale for evaluating physostigmine in ataxia, including Friedreich’s ataxia, is its inhibition of acetylcholinesterase, which prolongs central and peripheral effects of acetylcholine. The mechanism of action of Riluzole may be related to the small conductance calcium-activated potassium channels that appear to regulate excitability in neurons found within deep cerebellar nuclei. Amantadine may be helpfull in the treatment of the patients with Freidreich’s ataxia.

Medical Therapy

Medical Therapy

  • Pharmacologic medical therapy is recommended among patients with Friedreich’s ataxia but their affect in decrease the symptoms of Friedreich’s ataxia is not significant.[1]
  • Pharmacologic medical therapies for Friedreich’s ataxia include Physostigmine, Riluzole and Amantadine.

• Physostigmine

The rationale for evaluating physostigmine in ataxia, including Friedreich’s ataxia, is its inhibition of acetylcholinesterase, which prolongs central and peripheral effects of acetylcholine.[1]

• Riluzole

The mechanism of action of Riluzole may be related to the small conductance calcium-activated potassium channels that appear to regulate excitability in neurons found within deep cerebellar nuclei.

• Amantadine

Amantadine may be helpfull in the treatment of the patients with Freidreich’s ataxia.

References

References

  1. ↑ 1.0 1.1 Escudero E, Moreyra A, Iveli C, Lardani H, Cingolani HE (April 1973). “[Myocardial contractility: an experimental analysis of various proposed indices]”. Acta Physiol Lat Am (in Spanish; Castilian). 23 (4): 250–69. PMID 4768799.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]