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Reliable, easy-to-read patient information on common medical conditions β€” written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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GABRG3

Introduction

GABAA receptor-Ξ³3, also known as GABRG3, is a protein which in humans is encoded by the GABRG3 gene.

Function

Function

GABRG3 is a subunit of the GABAA receptor for the neurotransmitter gamma-Aminobutyric acid (GABA).[1]

Association with alcoholism

Association with alcoholism

Genetic markers near the GABRG3 gene are statistically linked to alcoholism.[2]

See also

See also

References

References

  1. ↑ “Entrez Gene: GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3”.
  2. ↑ Dick DM, Edenberg HJ, Xuei X, Goate A, Kuperman S, Schuckit M, Crowe R, Smith TL, Porjesz B, Begleiter H, Foroud T (January 2004). “Association of GABRG3 with alcohol dependence”. Alcohol. Clin. Exp. Res. 28 (1): 4–9. doi:10.1097/01.ALC.0000108645.54345.98. PMIDΒ 14745296.
Further reading

Further reading

  • Greger V, Knoll JH, Woolf E, et al. (1995). “The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation”. Genomics. 26 (2): 258–64. doi:10.1016/0888-7543(95)80209-5. PMIDΒ 7601451.
  • TΓΆgel M, Mossier B, Fuchs K, Sieghart W (1994). “gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties”. J. Biol. Chem. 269 (17): 12993–8. PMIDΒ 8175718.
  • Hadingham KL, Wafford KA, Thompson SA, et al. (1996). “Expression and pharmacology of human GABAA receptors containing gamma 3 subunits”. Eur. J. Pharmacol. 291 (3): 301–9. doi:10.1016/0922-4106(95)90070-5. PMIDΒ 8719414.
  • Poulsen CF, Christjansen KN, Hastrup S, Hartvig L (2000). “Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor”. Brain Res. Mol. Brain Res. 78 (1–2): 201–3. doi:10.1016/S0169-328X(00)00085-1. PMIDΒ 10891602.
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). “Creation of genome-wide protein expression libraries using random activation of gene expression”. Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMIDΒ 11329013.
  • Nymann-Andersen J, Wang H, Chen L, et al. (2002). “Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors”. J. Neurochem. 80 (5): 815–23. doi:10.1046/j.0022-3042.2002.00762.x. PMIDΒ 11948245.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMCΒ 139241. PMIDΒ 12477932.
  • Dick DM, Edenberg HJ, Xuei X, et al. (2004). “Association of GABRG3 with alcohol dependence”. Alcohol. Clin. Exp. Res. 28 (1): 4–9. doi:10.1097/01.ALC.0000108645.54345.98. PMIDΒ 14745296.
  • Gole L, Crolla JA, Thomas SN, et al. (2004). “Characterization of breakpoints in the GABRG3 and TSPY genes in a family with a t(Y;15)(p11.2;q12)”. Am. J. Med. Genet. A. 125 (2): 177–80. doi:10.1002/ajmg.a.20482. PMIDΒ 14981720.
External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.