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GCA (gene)
Introduction
Grancalcin, EF-hand calcium binding protein, also known as GCA, is a human gene.[1]
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.[1]
Further reading
Further reading
- Lim J, Hao T, Shaw C; et al. (2006). “A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Rual JF, Venkatesan K, Hao T; et al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Hillier LW, Graves TA, Fulton RS; et al. (2005). “Generation and annotation of the DNA sequences of human chromosomes 2 and 4”. Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Hansen C, Tarabykina S, la Cour JM; et al. (2003). “The PEF family proteins sorcin and grancalcin interact in vivo and in vitro”. FEBS Lett. 545 (2–3): 151–4. PMID 12804766.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Jia J, Borregaard N, Lollike K, Cygler M (2002). “Structure of Ca(2+)-loaded human grancalcin”. Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 12): 1843–9. PMID 11717497.
- Lollike K, Johnsen AH, Durussel I; et al. (2001). “Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner”. J. Biol. Chem. 276 (21): 17762–9. doi:10.1074/jbc.M100965200. PMID 11279160.
- Jia J, Han Q, Borregaard N; et al. (2000). “Crystal structure of human grancalcin, a member of the penta-EF-hand protein family”. J. Mol. Biol. 300 (5): 1271–81. doi:10.1006/jmbi.2000.3925. PMID 10903868.
- Maki M, Narayana SV, Hitomi K (1998). “A growing family of the Ca2+-binding proteins with five EF-hand motifs”. Biochem. J. 328 ( Pt 2): 718–20. PMID 9441591.
- Boyhan A, Casimir CM, French JK; et al. (1992). “Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes”. J. Biol. Chem. 267 (5): 2928–33. PMID 1737748.
- Teahan CG, Totty NF, Segal AW (1992). “Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils”. Biochem. J. 286 ( Pt 2): 549–54. PMID 1530588.