Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
GCM2
Introduction
Chorion-specific transcription factor GCMb is a protein that in humans is encoded by the GCM2 gene.[1][2]
The Drosophila ‘glial cells missing’ (gcm) gene is thought to act as a binary switch between neuronal and glial cell determination. The gcm protein and mammalian gcm homologs contain a conserved N-terminal gcm motif that has DNA-binding activity. See GCM1 (MIM 603715).[supplied by OMIM][2]
References
References
- ↑ Kanemura Y, Hiraga S, Arita N, Ohnishi T, Izumoto S, Mori K, Matsumura H, Yamasaki M, Fushiki S, Yoshimine T (Feb 1999). “Isolation and expression analysis of a novel human homologue of the Drosophila glial cells missing (gcm) gene”. FEBS Lett. 442 (2–3): 151–6. doi:10.1016/S0014-5793(98)01650-0. PMID 9928992.
- ↑ 2.0 2.1 “Entrez Gene: GCM2 glial cells missing homolog 2 (Drosophila)”.
Further reading
Further reading
- Kammerer M, Pirola B, Giglio S, Giangrande A (1999). “GCMB, a second human homolog of the fly glide/gcm gene”. Cytogenet. Cell Genet. 84 (1–2): 43–7. doi:10.1159/000015210. PMID 10343099.
- Correa P, Akerström G, Westin G (2002). “Underexpression of Gcm2, a master regulatory gene of parathyroid gland development, in adenomas of primary hyperparathyroidism”. Clin. Endocrinol. 57 (4): 501–5. doi:10.1046/j.1365-2265.2002.01627.x. PMID 12354132.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). “The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Maret A, Bourdeau I, Ding C, et al. (2004). “Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin”. J. Clin. Endocrinol. Metab. 89 (1): 8–12. doi:10.1210/jc.2003-030733. PMID 14715818.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Kebebew E, Peng M, Wong MG, et al. (2005). “GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism”. Surgery. 136 (6): 1261–6. doi:10.1016/j.surg.2004.06.056. PMID 15657585.
- Thomée C, Schubert SW, Parma J, et al. (2005). “GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone”. J. Clin. Endocrinol. Metab. 90 (5): 2487–92. doi:10.1210/jc.2004-2450. PMID 15728199.
- Baumber L, Tufarelli C, Patel S, et al. (2006). “Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism”. J. Med. Genet. 42 (5): 443–8. doi:10.1136/jmg.2004.026898. PMC 1736051. PMID 15863676.