Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
GKN1
Introduction
Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene.[1][2][3]
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa.[3]
References
References
- ↑ Martin TE, Powell CT, Wang Z, Bhattacharyya S, Walsh-Reitz MM, Agarwal K, Toback FG (Jul 2003). “A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa”. Am J Physiol Gastrointest Liver Physiol. 285 (2): G332–43. doi:10.1152/ajpgi.00453.2002. PMID 12851218.
- ↑ Shiozaki K, Nakamori S, Tsujie M, Okami J, Yamamoto H, Nagano H, Dono K, Umeshita K, Sakon M, Furukawa H, Hiratsuka M, Kasugai T, Ishiguro S, Monden M (Sep 2001). “Human stomach-specific gene, CA11, is down-regulated in gastric cancer”. Int J Oncol. 19 (4): 701–7. doi:10.3892/ijo.19.4.701. PMID 11562744.
- ↑ 3.0 3.1 “Entrez Gene: GKN1 gastrokine 1”.
Further reading
Further reading
- Yoshikawa Y, Mukai H, Hino F, et al. (2000). “Isolation of two novel genes, down-regulated in gastric cancer”. Jpn. J. Cancer Res. 91 (5): 459–63. doi:10.1111/j.1349-7006.2000.tb00967.x. PMID 10835488.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment”. Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Westley BR, Griffin SM, May FE (2005). “Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C”. Biochemistry. 44 (22): 7967–75. doi:10.1021/bi047287n. PMID 15924415.
- Walsh-Reitz MM, Huang EF, Musch MW, et al. (2005). “AMP-18 protects barrier function of colonic epithelial cells: role of tight junction proteins”. Am. J. Physiol. Gastrointest. Liver Physiol. 289 (1): G163–71. doi:10.1152/ajpgi.00013.2005. PMC 1444946. PMID 15961882.
- Nardone G, Rippa E, Martin G, et al. (2007). “Gastrokine 1 expression in patients with and without Helicobacter pylori infection”. Digestive and Liver Disease. 39 (2): 122–9. doi:10.1016/j.dld.2006.09.017. PMID 17092786.