Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
GPHA2
Introduction
Glycoprotein hormone alpha-2 is a protein that in humans is encoded by the GPHA2 gene.[1][2]
GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002).[supplied by OMIM][2]
References
References
- ↑ Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ (Jan 2002). “Activation of orphan receptors by the hormone relaxin”. Science. 295 (5555): 671–4. doi:10.1126/science.1065654. PMID 11809971.
- ↑ 2.0 2.1 “Entrez Gene: GPHA2 glycoprotein hormone alpha 2”.
Further reading
Further reading
- Suzuki C, Nagasaki H, Okajima Y, et al. (2007). “The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin”. Regul. Pept. 142 (1–2): 60–7. doi:10.1016/j.regpep.2007.01.009. PMID 17363077.
- Breous E, Wenzel A, Loos U (2006). “Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit”. Mol. Cell. Endocrinol. 245 (1–2): 169–80. doi:10.1016/j.mce.2005.11.009. PMID 16376481.
- Sudo S, Kuwabara Y, Park JI, et al. (2005). “Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5”. Endocrinology. 146 (8): 3596–604. doi:10.1210/en.2005-0317. PMID 15890769.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hsu SY, Nakabayashi K, Bhalla A (2003). “Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5”. Mol. Endocrinol. 16 (7): 1538–51. doi:10.1210/me.16.7.1538. PMID 12089349.
- Nakabayashi K, Matsumi H, Bhalla A, et al. (2002). “Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor”. J. Clin. Invest. 109 (11): 1445–52. doi:10.1172/JCI14340. PMC 150994. PMID 12045258.