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Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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GRK5

Introduction

G protein-coupled receptor kinase 5 is an enzyme that in humans is encoded by the GRK5 gene.[1][2]

Function

Function

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).[2]

References

References

  1. ↑ Kunapuli P, Benovic JL (Jun 1993). “Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family”. Proceedings of the National Academy of Sciences of the United States of America. 90 (12): 5588–92. doi:10.1073/pnas.90.12.5588. PMC 46766. PMID 7685906.
  2. ↑ 2.0 2.1 “Entrez Gene: GRK5 G protein-coupled receptor kinase 5”.
Further reading

Further reading

  • Komolov KE, Bhardwaj A, Benovic JL (Aug 2015). “Atomic Structure of GRK5 Reveals Distinct Structural Features Novel for G Protein-coupled Receptor Kinases”. The Journal of Biological Chemistry. 290 (34): 20629–47. doi:10.1074/jbc.M115.647297. PMC 4543624. PMID 26032409.
  • Bullrich F, Druck T, Kunapuli P, Gomez J, Gripp KW, Schlegelberger B, Lasota J, Aronson M, Cannizzaro LA, Huebner K (1995). “Chromosomal mapping of the genes GPRK5 and GPRK6 encoding G protein-coupled receptor kinases GRK5 and GRK6”. Cytogenetics and Cell Genetics. 70 (3–4): 250–4. doi:10.1159/000134045. PMID 7789183.
  • Kunapuli P, Gurevich VV, Benovic JL (Apr 1994). “Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5”. The Journal of Biological Chemistry. 269 (14): 10209–12. PMID 8144599.
  • Kunapuli P, Onorato JJ, Hosey MM, Benovic JL (Jan 1994). “Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5”. The Journal of Biological Chemistry. 269 (2): 1099–105. PMID 8288567.
  • Nagayama Y, Tanaka K, Hara T, Namba H, Yamashita S, Taniyama K, Niwa M (Apr 1996). “Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor”. The Journal of Biological Chemistry. 271 (17): 10143–8. doi:10.1074/jbc.271.17.10143. PMID 8626574.
  • Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ (May 1996). “Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C”. The Journal of Biological Chemistry. 271 (22): 13266–72. doi:10.1074/jbc.271.22.13266. PMID 8662816.
  • Fredericks ZL, Pitcher JA, Lefkowitz RJ (Jun 1996). “Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor”. The Journal of Biological Chemistry. 271 (23): 13796–803. doi:10.1074/jbc.271.23.13796. PMID 8662852.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Pronin AN, Carman CV, Benovic JL (Nov 1998). “Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation”. The Journal of Biological Chemistry. 273 (47): 31510–8. doi:10.1074/jbc.273.47.31510. PMID 9813065.
  • Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ (Nov 1998). “beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein”. Proceedings of the National Academy of Sciences of the United States of America. 95 (24): 14082–7. doi:10.1073/pnas.95.24.14082. PMC 24330. PMID 9826657.
  • Carman CV, Lisanti MP, Benovic JL (Mar 1999). “Regulation of G protein-coupled receptor kinases by caveolin”. The Journal of Biological Chemistry. 274 (13): 8858–64. doi:10.1074/jbc.274.13.8858. PMID 10085129.
  • Brenninkmeijer CB, Price SA, López Bernal A, Phaneuf S (Sep 1999). “Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium”. The Journal of Endocrinology. 162 (3): 401–8. doi:10.1677/joe.0.1620401. PMID 10467231.
  • Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (Jan 2000). “Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein”. The Journal of Biological Chemistry. 275 (1): 390–7. doi:10.1074/jbc.275.1.390. PMID 10617630.
  • Pronin AN, Morris AJ, Surguchov A, Benovic JL (Aug 2000). “Synucleins are a novel class of substrates for G protein-coupled receptor kinases”. The Journal of Biological Chemistry. 275 (34): 26515–22. doi:10.1074/jbc.M003542200. PMID 10852916.
  • Berrada K, Plesnicher CL, Luo X, Thibonnier M (Sep 2000). “Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation”. The Journal of Biological Chemistry. 275 (35): 27229–37. doi:10.1074/jbc.M002288200. PMID 10858434.
  • Zhou H, Yan F, Tai HH (Sep 2001). “Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases”. The Journal of Pharmacology and Experimental Therapeutics. 298 (3): 1243–51. PMID 11504827.
  • Blaukat A, Pizard A, Breit A, Wernstedt C, Alhenc-Gelas F, Muller-Esterl W, Dikic I (Nov 2001). “Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function”. The Journal of Biological Chemistry. 276 (44): 40431–40. doi:10.1074/jbc.M107024200. PMID 11517230.
  • Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ (Jan 2002). “G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95”. The Journal of Biological Chemistry. 277 (2): 1607–13. doi:10.1074/jbc.M107297200. PMID 11700307.
  • Warabi K, Richardson MD, Barry WT, Yamaguchi K, Roush ED, Nishimura K, Kwatra MM (Jun 2002). “Human substance P receptor undergoes agonist-dependent phosphorylation by G protein-coupled receptor kinase 5 in vitro”. FEBS Letters. 521 (1–3): 140–4. doi:10.1016/S0014-5793(02)02858-2. PMID 12067742.