Achlorhydria

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Achlorhydria and hypochlorhydria refer to states where the production of gastric acid in the stomach is absent or low, respectively. It is associated with various other medical problems.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Template:WS Template:WH

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Luke Rusowicz-Orazem, B.S.

Achlorhydria is caused by intrinsic and extrinsic changes in the gastrointestinal system, including uptake of antibodies and bacterial infection. Less commonly, it can be caused by cancer, a life-threatening cause requiring prompt diagnosis and treatment.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.

• Prior gastric bypass surgery
• Chronic gastric H. pylori infection
• Chronic proton pump inhibitor (PPI) use
• Autoimmune conditions, such as diabetes, autoimmune thyroid disease.
• Elderly individuals

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.

Template:WH Template:WS

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please help WikiDoc by adding more content here. It’s easy! Click here to learn about editing.

• Achlorhydria may result in increased bacterial growth in the stomach and duodenum. This increases the risk of several infectious diseases such as salmonellosis, typhoid fever, shigellosis, and various parasitic infections.
• Stomach acid is important in liberating minerals from food, thereby increasing the risk that individuals with hypochlorohydria or achlorhydria will develop calcium and zinc deficiencies.
• Loss of acid production may also alter the rate or extent of drug absorption.
• Atrophic gastritis, one of the complications of achlorhydria, has been considered to be a potential precursor to gastric carcinoma.

The outcome of achlorhydria depends on:

• The underlying cause of achlorhydria: If achlorhydria results from cancer or a surgical procedure, the prognosis is more guarded.
• The complications of achlorhydria: Atrophic gastritis, one of the complications of achlorhydria, has been considered to be a potential precursor to gastric carcinoma.

Template:WH Template:WS