Gastric chief cell

A gastric chief cell (or peptic cell, or gastric zymogenic cell) is a cell in the stomach that releases pepsinogen, gastric lipase and rennin. The cell stains basophilic upon H&E prep due to the large proportion of rough endoplasmic reticulum in it’s cytoplasm.

It works in conjunction with the parietal cell which releases gastric acid, converting the pepsinogen into pepsin.

The terms “chief cell” and “zymogenic cell” are often used without the word “gastric” to name this type of cell. However those terms can also be used to describe other cell types (for example, parathyroid chief cells).

• Gastric acid
• Fundic glands

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• Histology image: 22201loa – Histology Learning System at Boston University – “Ultrastructure of the Cell: chief cells and enteroendocrine cell”
• Histology image: 11304loa – Histology Learning System at Boston University – “Digestive System: Alimentary Canal: fundic stomach, gastric glands, base”
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• Essentials of Human Physiology by Thomas M. Nosek. Section 6/6ch4/s6ch4_8.

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