Gastroesophageal reflux disease causes

Common causes of GERD include obesity, autonomic neuropathy, systemic sclerosis, esophageal achalasia, and hiatus hernia. Other causes of GERD include hypochlorhydria, hypercalcemia, and Zollinger-Ellison syndrome.

• Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.There are no life-threatening causes of GERD.

Common causes of GERD include the following:^[1]

• Obesity
• Hereditary sensory and autonomic neuropathy type 1B
• Esophageal achalasia
• Ibuprofen lysine
• Hiatus hernia
• Pharyngeal pouch

Less common causes of GERD include the following:

• Hypochlorhydria
• Hypercalcemia, which can increase gastrin production, leading to increased acidity.
• Zollinger-Ellison syndrome, which can be present with increased gastric acidity due to gastrin production.
• Scleroderma and systemic sclerosis, which can feature esophageal dysmotility.

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