Health Dictionary
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Gestational trophoblastic neoplasia staging
Introduction
Overview
Overview
According to the Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) cancer staging system, there are 4 stages of gestational trophoblastic neoplasia (GTN).
Staging
Staging
The Féderation Internationale de Gynécologie et d’Obstétrique (FIGO) staging system [1]
| Stage | FIGO Anatomical Staging |
|---|---|
|
I |
|
|
II |
GTN extends outside of the uterus, but is limited to the genital structures (adnexa, vagina, broad ligament) |
|
III |
GTN extends to the lungs, with or without known genital tract involvement |
|
IV |
All other metastatic sites |
Modified WHO prognostic scoring system as adapted by Fédération Internationale de Gynécologie et d’Obstétrique (FIGO)[2]
| Score | 0 | 1 | 3 | 4 |
|---|---|---|---|---|
| Age | < 40 | 40 | – | – |
| Antecedent pregnancy | Mole | Abortion | Term | – |
| Interval months from index pregnancy | < 4 | 4 – < 7 | 7 – < 13 | ≥ 13 |
| Pre-treatment serum βhCG
(iu/l) |
< 103 | 103 – < 104 | 104 – < 105 | ≥ 105 |
| Largest tumor size (including uterus) | – | 3 – < 5 cm | ≥ 5cm | – |
| Site of metastases | Lung | Spleen, Kidney | Gastrointestinal | Liver, Brain |
| Number of metastases | – | 1 – 4 | 5 – 8 | > 8 |
| Previous failed chemotherapy | – | – | 1 drug | 2 or more drugs |
References
References
- ↑ Stage Information for Gestational Trophoblastic Disease. National Cancer Institute. http://www.cancer.gov/types/gestational-trophoblastic/hp/gtd-treatment-pdq#section/_11 URL Accessed on October 7, 2015
- ↑ Ngan HY, Bender H, Benedet JL, Jones H, Montruccoli GC, Pecorelli S (October 2003). “Gestational trophoblastic neoplasia, FIGO 2000 staging and classification”. Int J Gynaecol Obstet. 83 Suppl 1: 175–7. PMID 14763174.
Editor-In-Chief:
C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]Sabawoon Mirwais, M.B.B.S, M.D.[3]