Glanzmann’s thrombasthenia is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a severe hemorrhage after a surgery, such as circumcision. The severity of the presenting symptoms has no known relation to the affected gene. However, mutations in the ITGB3 gene manifest bleeding more than the other gene. Symptoms of Glanzmann’s thrombasthenia varies from a minor bruise to a life-threatening hemorrhage. It may include easily bruising (76.6%), nosebleeds that do not stop easily (62.5%), bleeding gums (56.4%), prolonged bleeding with minor injuries (47.2%), heavy menstrual bleeding, postpartum bleeding, gastrointestinal bleeding, heavy bleeding during and after surgery and bleeding into joints (rare).

Glanzmann’s thrombasthenia is diagnosed at the neonatal age or early childhood, commonly before the age of 5 and the early manifestations are mostly easily bruising, mucocutaneous bleeding, epistaxis due to digital manipulation or a severe hemorrhage after a surgery, such as circumcision. The severity of the presenting symptoms has no known relation to the affected gene. However, mutations in the ITGB3 gene manifest bleeding more than the other gene.^[1]

Symptoms of Glanzmann’s thrombasthenia vary from a minor bruise to a life-threatening hemorrhage^[1]. It may include any of the following manifestations:^[1][2][3][4]

• Easily bruising (76.6%)
• Nosebleeds that do not stop easily (62.5%)
• Bleeding gums (56.4%)
• Prolonged bleeding with minor injuries (47.2%)
• Heavy menstrual bleeding
• Postpartum bleeding
• Gastrointestinal bleeding
• Heavy bleeding during and after surgery
• Bleeding into joints (rare) ^[5]