Gliomatosis cerebri other imaging findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Other imaging studies for gliomatosis cerebri include MR spectroscopy (decreased N-Acetylaspartic acid (NAA)/creatine ratio and elevated choline/creatine ratio, choline/NAA ratio, and myoinositol), MR perfusion (low/normal relative cerebral blood flow), PET scan (markedly decreased accumulation of [18F]-fluorodeoxyglucose on F-18 FDG PET, hypermetabolism on C-11 methionine PET, and marked increase in cerebral blood flow on 15(O)-water PET), and bone scan (metastasis to bones).

Other Imaging Findings

Other imaging studies for gliomatosis cerebri include:^[1]^[2]^[3]

1. Magnetic Resonance Spectroscopy

MR spectroscopy may be helpful in the diagnosis of gliomatosis cerebri. Findings on MR spectroscopy suggestive of gliomatosis cerebri include:^[1]^[3]

Decreased N-Acetylaspartic acid (NAA)/creatine ratio
Elevated choline/creatine ratio
Elevated choline/NAA ratio
Elevated myoinositol

2. Magnetic Resonance Perfusion

MR perfusion may be helpful in the diagnosis of gliomatosis cerebri. Findings on MR perfusion suggestive of gliomatosis cerebri include:^[1]

Low/normal relative cerebral blood flow (no vascular hyperplasia)

3. Positron Emission Tomography

PET scan may be helpful in the diagnosis of gliomatosis cerebri. Findings on PET scan suggestive of gliomatosis cerebri include:^[1]^[2]

F-18 FDG PET images show markedly decreased accumulation of [18F]-fluorodeoxyglucose (glucose hypometabolism).
C-11 methionine PET images show hypermetabolism.
15(O)-water PET images show a marked increase in cerebral blood flow in gliomatosis cerebri lesions.

4. Bone Scan

Most malignant gliomas get metastasized to the bones via the hematogenous spread.^[4]
Bone scan may be performed to detect metastases of gliomatosis cerebri to bones.

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Radiographic features of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri
↑ ^2.0 ^2.1 Rajz GG, Nass D, Talianski E, Pfeffer R, Spiegelmann R, Cohen ZR (2012). “Presentation patterns and outcome of gliomatosis cerebri”. Oncol Lett. 3 (1): 209–213. doi:10.3892/ol.2011.445. PMC 3362440. PMID 22740882.
↑ ^3.0 ^3.1 Desclée P, Rommel D, Hernalsteen D, Godfraind C, de Coene B, Cosnard G (2010). “Gliomatosis cerebri, imaging findings of 12 cases”. J Neuroradiol. 37 (3): 148–58. doi:10.1016/j.neurad.2009.12.001. PMID 20334921.
↑ Beauchesne P (2011). “Extra-neural metastases of malignant gliomas: myth or reality?”. Cancers (Basel). 3 (1): 461–77. doi:10.3390/cancers3010461. PMC 3756372. PMID 24212625.CS1 maint: PMC format (link)

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[aaa-1] 1.0 ^1.1 ^1.2 ^1.3 Radiographic features of gliomatosis cerebri. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/gliomatosis-cerebri

[pmid22740882-2] 2.0 ^2.1 Rajz GG, Nass D, Talianski E, Pfeffer R, Spiegelmann R, Cohen ZR (2012). “Presentation patterns and outcome of gliomatosis cerebri”. Oncol Lett. 3 (1): 209–213. doi:10.3892/ol.2011.445. PMC 3362440. PMID 22740882.

[pmid20334921-3] 3.0 ^3.1 Desclée P, Rommel D, Hernalsteen D, Godfraind C, de Coene B, Cosnard G (2010). “Gliomatosis cerebri, imaging findings of 12 cases”. J Neuroradiol. 37 (3): 148–58. doi:10.1016/j.neurad.2009.12.001. PMID 20334921.

[pmid24212625-4] Beauchesne P (2011). “Extra-neural metastases of malignant gliomas: myth or reality?”. Cancers (Basel). 3 (1): 461–77. doi:10.3390/cancers3010461. PMC 3756372. PMID 24212625.CS1 maint: PMC format (link)

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