Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Glucocorticoid resistance
Introduction
Synonyms and keywords: Cortisol resistance; glucocorticoid insensitivity; steroid hormone resistance; glucocorticoid receptor, steroid hormone insensitivity; overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations; elevations in circulating cortisol; mineralocorticoid excess; androgen excess
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Overview
Overview
Patients can be both resistant and hypersensitive to glucocorticoids.
In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be
- Generalized or tissue-specific
- Transient or permanent
- Partial or complete
- Compensated or noncompensated.
The presence of complete glucocorticoid resistance is fatal. Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.
Acknowledgements
Acknowledgements
The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]