Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Glucose-6-phosphate dehydrogenase deficiency historical perspective
Introduction
Overview
Overview
G6PD deficiency was first discovered more than 50 years ago. Prisoner volunteers were given primaquine and some of them developed hemolytic anemia
Historical Perspective
Historical Perspective
Discovery
- G6PD deficiency was first discovered more than 50 years ago.[1]
- The association between primaquine and discovery of G6PD deficiency was made during a study at Illinois State Penitentiary. Prisoner volunteers were given primaquine and some of them developed hemolytic anemia.[2]
- Numerous soldiers developed hemolytic anemia after taking primaquine to prevent relapsing infection by plasmodium vivax during Korean War. Most of them are from North African and Mediterranean.
References
References
- ↑ Beutler E (January 2008). “Glucose-6-phosphate dehydrogenase deficiency: a historical perspective”. Blood. 111 (1): 16–24. doi:10.1182/blood-2007-04-077412. PMID 18156501.
- ↑ Baird K (May 2015). “Origins and implications of neglect of G6PD deficiency and primaquine toxicity in Plasmodium vivax malaria”. Pathog Glob Health. 109 (3): 93–106. doi:10.1179/2047773215Y.0000000016. PMC 4455359. PMID 25943156.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]