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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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GlyCAM-1

Introduction

Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.[1][2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin. Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[3]

GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.[1]

External links
References

References

  1. ↑ 1.0 1.1 Imhof, Beat A.; Dunon, Dominique. Leukocyte Migration and Adhesion. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9.
  2. ↑ “Identification of a soluble form of a ligand for the lymphocyte homing receptor”. The Journal of Experimental Medicine. 176 (5): 1415–1419. 1 November 1992. PMC 2119429. PMID 1383387.
  3. ↑ Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). “Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk”. The Journal of Clinical Investigation. 92 (2): 952–60. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.