Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Glypican 5
Introduction
Glypican-5 is a protein that in humans is encoded by the GPC5 gene.[1][2]
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.[2]
References
References
- ↑ Veugelers M, Vermeesch J, Reekmans G, Steinfeld R, Marynen P, David G (Jun 1997). “Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family”. Genomics. 40 (1): 24–30. doi:10.1006/geno.1996.4518. PMID 9070915.
- ↑ 2.0 2.1 “Entrez Gene: GPC5 glypican 5”.
Further reading
Further reading
- De Cat B, David G (2001). “Developmental roles of the glypicans”. Semin. Cell Dev. Biol. 12 (2): 117–25. doi:10.1006/scdb.2000.0240. PMID 11292377.
- Watanabe K, Yamada H, Yamaguchi Y (1995). “K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney”. J. Cell Biol. 130 (5): 1207–18. doi:10.1083/jcb.130.5.1207. PMC 2120559. PMID 7657705.
- Saunders S, Paine-Saunders S, Lander AD (1997). “Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain”. Dev. Biol. 190 (1): 78–93. doi:10.1006/dbio.1997.8690. PMID 9331333.
- Veugelers M, De Cat B, Delande N, et al. (2002). “A 4-Mb BAC/PAC contig and complete genomic structure of the GPC5/GPC6 gene cluster on chromosome 13q32”. Matrix Biol. 20 (5–6): 375–85. doi:10.1016/S0945-053X(01)00143-3. PMID 11566272.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yu W, Inoue J, Imoto I, et al. (2004). “GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines”. J. Hum. Genet. 48 (6): 331–5. doi:10.1007/s10038-003-0026-2. PMID 12721791.
- Dunham A, Matthews LH, Burton J, et al. (2004). “The DNA sequence and analysis of human chromosome 13”. Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.