Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Gonadoblastoma historical perspective
Introduction
Overview
Overview
Gonadoblastoma was first discovered by Dr. Scully in 1953. The association between GBY gene (GonadoBlastoma on the Y chromosome) and gonadoblastoma was made in 1986. In 1995, Tsuchiya found that the GBY gene located near the centromere of Y chromosome and contains multiple genes including Testis-specific protein Y-encoded (TSPY) gene.
Historical Perspective
Historical Perspective
- Gonadoblastoma was first discovered by Dr. Scully, an American pathologist, in 1953 studying the pathology of a series of tumors suspected of being dysgerminomas.[1][2][3][4]
- This tumor is called gonadoblastoma since it looks like embryonic tissue, but in an indifferent way regarding sexual development.
- The association between GBY gene (GonadoBlastoma on Y chromosome) and gonadoblastoma was made in 1986.
- In 1995, Tsuchiya found that the GBY gene located near the centromere of Y chromosome and contains multiple genes including testis-specific protein Y-encoded (TSPY) gene.
References
References
- ↑ Scully, Robert E. (1953). “Gonadoblastoma. A gonadal tumor related to the dysgerminoma (Seminoma) and capable of sex-hormone production”. Cancer. 6 (3): 455–463. doi:10.1002/1097-0142(195305)6:3<455::AID-CNCR2820060303>3.0.CO;2-U. ISSN 0008-543X.
- ↑ Scully RE (1970). “Gonadoblastoma. A review of 74 cases”. Cancer. 25 (6): 1340–56. PMID 4193741.
- ↑ Page DC (1987). “Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads”. Development. 101 Suppl: 151–5. PMID 3503713.
- ↑ Tsuchiya K, Reijo R, Page DC, Disteche CM (December 1995). “Gonadoblastoma: molecular definition of the susceptibility region on the Y chromosome”. Am. J. Hum. Genet. 57 (6): 1400–7. PMC 1801429. PMID 8533770.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2]