Goodpasture syndrome history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3] Akshun Kalia M.B.B.S.[4]

Overview

Obtaining a complete history is an important aspect of making a diagnosis of Goodpasture syndrome, as it can provide insight into cause, precipitating factors, and associated underlying conditions. Specific areas of focus are past medical history (any recent upper respiratory tract infection), and any family history of autoimmune disease. Symptoms may develop acutely or rapidly affecting the renal and pulmonary system. Symptoms of Goodpasture syndrome include malaise, pyrexia and chills and arthralgia, fatigue, lethargy, pallor, and anorexia.

History and Symptoms

History

Obtaining history is an important aspect in making a diagnosis of Goodpasture syndrome. It provides insight into cause, precipitating factors and associated comorbid conditions. Complete history will help determine the correct therapy and helps in determining the prognosis. Specific histories about the symptoms (duration, onset, progression), associated symptoms, drug usage have to be obtained. Specific areas of focus when obtaining the history, are outlined below:

Past medical history (any recent upper respiratory tract infection)
Any family history of autoimmune disease
Urinary changes (frequency, dysuria or color change)
Breathing difficulty
Fatigue
Fever

Symptoms

The symptoms of Goodpasture syndrome may develop very slowly over the course of months or even years, but in majority of patients they develop quickly over days to weeks. Common symptoms of Goodpasture syndrome include loss of appetite, low grade fever, fatigue, and weakness.^[1]^[2]

Pulmonary symptoms may include:^[1]^[3]

Dry cough
Coughing up blood (most concerning for patients)
Exertional shortness of breath
Paleness of eyes and nail
Chest pain (less frequently)

Renal and other symptoms include:^[1]^[4]^[5]

References

↑ ^1.0 ^1.1 ^1.2 Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G; et al. (2015). “Goodpasture’s syndrome: a clinical update”. Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.
↑ Hellmark T, Segelmark M (2014). “Diagnosis and classification of Goodpasture’s disease (anti-GBM)”. J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
↑ Hellmark T, Segelmark M (2014). “Diagnosis and classification of Goodpasture’s disease (anti-GBM)”. J. Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
↑ Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G, Martellucci S, Turchetta R, Longo L, De Vincentiis M (March 2015). “Goodpasture’s syndrome: a clinical update”. Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.
↑ Halgrimson CG, Wilson CB, Dixon FJ, Anderson JT, Ogden DA, Starzl TE (August 1971). “Goodpasture’s syndrome. Treatment with nephrectomy and renal transplantation”. Arch Surg. 103 (2): 283–9. PMC 2980293. PMID 4935099.

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[pmid25462583-1] 1.0 ^1.1 ^1.2 Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G; et al. (2015). “Goodpasture’s syndrome: a clinical update”. Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.

[pmid24456936-2] Hellmark T, Segelmark M (2014). “Diagnosis and classification of Goodpasture’s disease (anti-GBM)”. J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.

[pmid244569362-3] Hellmark T, Segelmark M (2014). “Diagnosis and classification of Goodpasture’s disease (anti-GBM)”. J. Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.

[pmid254625832-4] Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Pagliuca G, Martellucci S, Turchetta R, Longo L, De Vincentiis M (March 2015). “Goodpasture’s syndrome: a clinical update”. Autoimmun Rev. 14 (3): 246–53. doi:10.1016/j.autrev.2014.11.006. PMID 25462583.

[pmid4935099-5] Halgrimson CG, Wilson CB, Dixon FJ, Anderson JT, Ogden DA, Starzl TE (August 1971). “Goodpasture’s syndrome. Treatment with nephrectomy and renal transplantation”. Arch Surg. 103 (2): 283–9. PMC 2980293. PMID 4935099.

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