Laboratory findings consistent with the diagnosis of Goodpasture syndrome include presence of autoantibodies such as anti-glomerular basement membrane antibodies. Other findings associated with pulmonary and renal injury include elevated blood urea nitrogen, low-grade proteinuria, gross or microscopic hematuria, and red cell casts.

Laboratory findings consistent with the diagnosis of Goodpasture syndrome include presence of autoantibodies such as anti-glomerular basement membrane antibodies.^[1][2][3]

• Other findings associated with pulmonary and renal injury include elevated blood urea nitrogen, low-grade proteinuria, gross or microscopic hematuria, and red cell casts.
• If laboratory test cannot detect the presence of anti-glomerular basement membrane antibodies, other tests such as anti-neutrophil cytoplasmic antibodies (ANCA) should be done to determine and rule out the presence of ANCA associated vasculitis.^[4]
• Routine laboratory test that may be ordered to help in identifying the cause are:
  • Complete blood count (leukocytosis and anemia)
  • Renal function test (BUN, S. creatinine)
  • Urinalysis for proteinuria, hematuria, and red cell casts
  • ESR and CRP
• Pulmonary function testing (PFT) may be done to determine the extent of disease as patients with Goodpasture syndrome tend to have interstitial fibrosis and a restrictive pattern on PFTs.
• The diffusing capacity for carbon monoxide (DLCO) is also elevated due to destruction of alveolar basement membrane and subsequent fibrosis.