Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
HELLS
Introduction
Lymphoid-specific helicase is an enzyme that in humans is encoded by the HELLS gene.[1][2][3]
This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]
References
References
- ↑ Geiman TM, Durum SK, Muegge K (Feb 1999). “Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh)”. Genomics. 54 (3): 477–83. doi:10.1006/geno.1998.5557. PMID 9878251.
- ↑ Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, Wilkins BJ, Kim JM, Blough RI, Arceci RJ (Aug 2000). “Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia”. Cancer Res. 60 (13): 3612–22. PMID 10910076.
- ↑ 3.0 3.1 “Entrez Gene: HELLS helicase, lymphoid-specific”.
Further reading
Further reading
- Ohira M, Morohashi A, Nakamura Y, et al. (2003). “Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma”. Cancer Lett. 197 (1–2): 63–8. doi:10.1016/S0304-3835(03)00085-5. PMID 12880961.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). “A “double adaptor” method for improved shotgun library construction”. Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Hillier LD, Lennon G, Becker M, et al. (1997). “Generation and analysis of 280,000 human expressed sequence tags”. Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Yu W, Andersson B, Worley KC, et al. (1997). “Large-Scale Concatenation cDNA Sequencing”. Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sun LQ, Lee DW, Zhang Q, et al. (2004). “Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG”. Genes Dev. 18 (9): 1035–46. doi:10.1101/gad.1176104. PMC 406293. PMID 15105378.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). “The DNA sequence and comparative analysis of human chromosome 10”. Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Yano M, Ouchida M, Shigematsu H, et al. (2004). “Tumor-specific exon creation of the HELLS/SMARCA6 gene in non-small cell lung cancer”. Int. J. Cancer. 112 (1): 8–13. doi:10.1002/ijc.20407. PMID 15305370.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.