Health Dictionary
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HEPN1
Introduction
Hepatocellular carcinoma, down-regulated 1 is a protein that in humans is encoded by the HEPN1 gene. [1]
Function
Function
This gene is expressed in the liver, and encodes a short peptide that is localized predominantly to the cytoplasm. Transient transfection studies showed that expression of this gene significantly inhibited cell growth, and it may have a role in apoptosis. Expression of this gene is downregulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). Also to note is that this gene maps to the 3′-noncoding region of HEPACAM gene (GeneID:220296) on the antisense strand (PMID:15885354).
References
References
- ↑ “Entrez Gene: Hepatocellular carcinoma, down-regulated 1”. Retrieved 2017-09-12.
Further reading
Further reading
- Peng H, Fan J, Wu J, Lang J, Wang J, Liu H, Zhao S, Liao J (2013). “Silencing of HEPN1 is responsible for the aggressive biological behavior of pituitary somatotroph adenomas”. Cell. Physiol. Biochem. 31 (2–3): 379–88. doi:10.1159/000343375. PMID 23548416.
- Kim HS, Jung G (2014). “Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor”. FEBS Lett. 588 (23): 4413–21. doi:10.1016/j.febslet.2014.10.011. PMID 25448679.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.