Developer site: The content shown here is test data.

MyEClinic
MyEClinic
Health Dictionary AI Health Chat Find an Online Doctor
A serene Zen garden with raked sand and smooth stones, symbolising clarity and calm

Health Dictionary

Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

Back to skin conditions

HIV associated nephropathy surgery

Introduction

Overview

Overview

Kidney transplantation is increasing in HIV-positive patients with end-stage renal disease (ESRD).[1] Although the rejection rate is high, the graft survival rates are high.[2][3] Recently reports have shown successful kidney transplantation from HIV-positive donors to HIV-positive recipients.[4][5]

HIV Associated Nephropathy Surgery

HIV Associated Nephropathy Surgery

Kidney Transplantation

  • Kidney transplantation in HIV-positive patients with end-stage renal disease (ESRD) is increasing.[1]
  • A study reported a two to threefold increase in kidney rejection in patients with HIV-positive compared to HIV-negative.[2].
  • In one study the incidence of rejection was 31% and 41% at 1 and 3 years, respectively.[2] In another study the acute rejection rate was 18% and 27% at 1 and 3 years, respectively.[3]
  • The high rejection rate require more effective immunotherapy.[2]
  • Graft survival rates were 90.4% and 73.7% at 1 and 3 years,[2] respectively in one study and 100% and 81%, respectively in another study.[3]
  • Recently, there have been reports of successful kidney transplantation from HIV-positive donors to HIV-positive recipients.[4][5]
    • HIV superinfection and resistance to cART are among the most concerning risks in kidney transplantation in HIV-positive kidneys to HIV-positive recipients.[6]
References

References

  1. ↑ 1.0 1.1 Palau L, Menez S, Rodriguez-Sanchez J, Novick T, Delsante M, McMahon BA; et al. (2018). “HIV-associated nephropathy: links, risks and management”. HIV AIDS (Auckl). 10: 73–81. doi:10.2147/HIV.S141978. PMC 5975615. PMID 29872351.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Stock PG, Barin B, Murphy B, Hanto D, Diego JM, Light J; et al. (2010). “Outcomes of kidney transplantation in HIV-infected recipients”. N Engl J Med. 363 (21): 2004–14. doi:10.1056/NEJMoa1001197. PMC 3028983. PMID 21083386.
  3. ↑ 3.0 3.1 3.2 Waheed S, Sakr A, Chheda ND, Lucas GM, Estrella M, Fine DM; et al. (2015). “Outcomes of Renal Transplantation in HIV-1 Associated Nephropathy”. PLoS One. 10 (6): e0129702. doi:10.1371/journal.pone.0129702. PMC 4463848. PMID 26061701.
  4. ↑ 4.0 4.1 Muller E, Barday Z, Mendelson M, Kahn D (2015). “HIV-positive-to-HIV-positive kidney transplantation–results at 3 to 5 years”. N Engl J Med. 372 (7): 613–20. doi:10.1056/NEJMoa1408896. PMC 5090019. PMID 25671253.
  5. ↑ 5.0 5.1 Durand CM, Segev D, Sugarman J (2016). “Realizing HOPE: The Ethics of Organ Transplantation From HIV-Positive Donors”. Ann Intern Med. 165 (2): 138–42. doi:10.7326/M16-0560. PMC 4949150. PMID 27043422.
  6. ↑ Muller E, Barday Z (2018). “HIV-Positive Kidney Donor Selection for HIV-Positive Transplant Recipients”. J Am Soc Nephrol. 29 (4): 1090–1095. doi:10.1681/ASN.2017080853. PMC 5875954. PMID 29330339.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]