Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
HIV coinfection with tuberculosis natural history, complications and prognosis
Introduction
Please help WikiDoc by adding content here. It’s easy! Click here to learn about editing.
Natural History
Natural History
Until the a couple of years ago Tuberculosis was visualised in a dichotomous state of Latent phase or Active disease.But with the recent advances in the Imaging modalities and screening tests TB is conceptualized as a continuous spectrum of disease stages from latent to subclinical to symptomatic, active disease.
- In people with HIV and Mild immuno-suppression ,it usually presents as in people without hiv i.e as pulmonary tuberculosis.
- People with HIV infection who have severe immunosuppression (CD4+ T-lymphocyte count, <200 per microliter)most commonly present to the clinic with Extra Pulmonary Tuberculosis.The most common sites being Lymph nodes,Liver,Spleen, Serosal surfaces ( resulting in Effusions) and CNS.
People with severe immunosuppreession can have accelerated progression of disease course and many a times it mimics acute bacterial infections.