HLA-A23

HLA-A23 (A23) is an HLA–A serotype. A23 is a split antigen serotype represented by the A9 broad antigen serotype. A closely related type is A24. A23 is common in Africa and regions of the Middle East, Mediterranean, and India. The mode for A23 is in western africa and two regions, Carmeroon and Senegal have frequencies approaching 20%. Outside of West Africa some increase is seen in small areas of India, most regions outside of africa A23 falls between 0 and 5%.

Serotype

A23 serotype recognition of some HLA A*23 allele-group gene products^[1]
A*23	A23	A24	Sample
allele	%	%	size (N)
2301	95	1	5119
2302	>50		2

Disease Associations

A*23:Cw*07 is associated with higher viral load in HIV^[2]

A23-B Haplotypes

A23-B7 is found in N.Afr. and S.Afr non-caucasians.
A23-B44 is found in Albania, Zimbabwe, Morocco, Spain and Danes.
A23-B58 is found in the !kung and Zaire.

References

↑ derived from IMGT/HLA
↑ Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R (2002). “Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1”. J Virol. 76 (16): 8276–84. PMID 12134033.

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[1] rived from IMGT/HLA

[HIV1_HLAI-2] Tang J, Tang S, Lobashevsky E, Myracle A, Fideli U, Aldrovandi G, Allen S, Musonda R, Kaslow R (2002). “Favorable and unfavorable HLA class I alleles and haplotypes in Zambians predominantly infected with clade C human immunodeficiency virus type 1”. J Virol. 76 (16): 8276–84. PMID 12134033.

[1]

[2]

HLA-A23

Serotype

Disease Associations

A23-B Haplotypes

References

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