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HLA-A66

Introduction

Overview

Overview

HLA-A66 (A66) is an HLA–A serotype. The serotype identifies the more common HLA-A*66 gene products. A66 is a split antigen type of the A10 broad antigen type. A*6601 is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[1] A66 is more common in Africa and SW Europe. A66 is uncommon.

Serotype

Serotype

A66, A10 serotype recognition of Some HLA A*66 allele-group gene products[2]
A*66 A66 A10 A26 Other Sample
allele % % % % size (N)
6601 20 10 61 3 799
6602 38 10 4 31 205
6603 32 7 7 18 28
A*6601 Frequencies

A*6601 Frequencies

HLA A*6601 frequencies
freq
ref. Population (%)
[3] Cameroon Sawa 7.7
[3] Kenya Luo 6.8
[3] Cameroon Sawa 7.7
[3] Cameroon Bakola Pygmy 5.8
[3] Cameroon Baka Pygmy 5.0
[3] Kenya Nandi 5.0
[3] Zimbabwe Harare Shona 0.2
[3] Cameroon Baka Pygmy 5.0
[3] Cameroon Beti 4.6
[3] Cameroon Bamileke 4.5
[3] India West Bhils 4.0
[3] Zimbabwe Harere Shona 3.8
[3] Uganda Kampala 3.8
[3] India Mumbia Marathas 2.5
[3] Cape Verde Northwestern 2.5
[3] Czech republic 2.4
[3] Morocco Nador Metalsa 2.1
[3] Central Portugal 2.0
[3] India West Parsis 2.0
[3] South Africian Natal Zulu 2.0
[3] Kenya 1.7
[3] Tunisia Tunis 1.7
[3] Guinea Bissau 1.5
[3] Georgia Tibilisi 1.4
[3] Zambia Lusaka 1.2
[3] Italy Bergamo 1.1
[3] Pakistan Karachi Parsi 1.1
[3] Oman 0.8
[3] Sudanese 0.8
[3] Belgium 0.5
[3] Southeast France 0.4
[3] Mongolia Buriat 0.4
[3] Wales 0.2
HLA A*6602 frequencies
freq
ref. Population (%)
[3] South Africian Natal Zulu 1.5
[3] Cameroon Yaounde 1.1
[3] Cameroon Bamileke 0.6
[3] Senegal Niokholo Mandenka 0.5
[3] Kenya Nandi 0.4
[3] Zimbabwe Harare Shona 0.2
[3] Wales 0.03
HLA A*6603 frequencies
freq
ref. Population (%)
[3] Cameroon Pygmy Baka 10.0
[3] Cameroon Bakola Pygmy 9.0
[3] Cameroon Sawa 7.7
[3] CAR Mbenzele Pygmy 2.8
[3] Zimbabwe Harare Shona 0.2
References

References

  1. ↑ Madrigal JA, Hildebrand WH, Belich MP; et al. (1993). “Structural diversity in the HLA-A10 family of alleles: correlations with serology”. Tissue Antigens. 41 (2): 72–80. PMID 8475492.
  2. ↑ derived from IMGT/HLA
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 3.25 3.26 3.27 3.28 3.29 3.30 3.31 3.32 3.33 3.34 3.35 3.36 3.37 3.38 3.39 3.40 3.41 3.42 3.43 3.44 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). “New allele frequency database: http://www.allelefrequencies.net“. Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]