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HLA-A74

Introduction

HLA-A74 (A74) is an HLA–A serotype. The serotype identifies the HLA-A*7401 gene product. A74 is a split antigen type of the A19 broad antigen type. A74 is rare.

Serotype

Serotype

A74, A19 serotype recognition of Some HLA A*74 allele-group gene products[1]
A*74 A74 A19 Sample
allele % % size (N)
7401 40 11 119
7401 17 29

Disease associations

A significant association has been found between A74 and nasal polyposis.[2]

A*74 allele Frequencies

A*74 allele Frequencies

HLA A*7401 frequencies
freq
ref. Population (%)
[3] Kenya 9.7
[3] Cameroon Beti 8.3
[3] Guinea Bissau 7.7
[3] Burkina Faso Mossi 6.6
[3] Uganda Kampala 5.2
[3] Cameroon Yaounde 5.0
[3] Cameroon Bamileke 4.5
[3] Cameroon Sawa 3.8
[3] Mali Bandiagara 3.6
[3] Iran Baloch 2.8
[3] Zimbabwe Harare Shona 2.7
[3] Senegal Niokholo Mandenka 2.2
[3] Burkina Faso Rimaibe 2.1
[3] Kenya Nandi 1.7
[3] Morocco Nador Metalsa 1.4
[3] Thailand Northeast 1.2
[3] Thailand 1.1
[3] Jordon Amman 0.7
[3] Jordon Amman 0.5
[3] China South 0.5
HLA A*7403 frequencies
freq
ref. Population (%)
[3] Kenya Luo 7.3
[3] Iran Baloch 0.6
[3] Kenya 0.3
[3] Uganda Kampala 0.3
References

References

  1. ↑ derived from IMGT/HLA
  2. ↑ Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D (2000). “HLA patterns in patients with nasal polyposis”. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery. 257 (3): 137–9. PMID 10839486.
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). “New allele frequency database: http://www.allelefrequencies.net“. Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)


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