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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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HLA-B*82

Introduction

HLA-B*82 (B*82) is an HLA–B allele-group. There is no current useful serotyping for HLA-B*82 gene products.[1] B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele.[2], later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.[3]

Serotype

Serotype

B82 serotype recognition of Some HLA B*82 allele-group gene products[4]
B*82 B82 other Sample
allele % % size (N)
8201 3 79 146

Allele frequencies

HLA B*8201 frequencies
freq
ref. Population (%)
[5] Luo (Kenya) 1.9
[5] Guinea Bissau 0.8
[5] Natal Zulu (S. Africa) 0.5
[5] Beti (Cameroon) 0.3
[5] Kenya 0.3
[5] Kampala (Uganda) 0.3
[5] Nandi (Kenya) 0.2
‘
HLA B*8202 frequencies
[5] Sudanese 2.5
[5] Kenya 0.7
[5] Guraiat and Hail (Saudi Arabia) 0.2
References

References

  1. ↑ Marsh SG, Albert ED, Bodmer WF; et al. (2005). “Nomenclature for factors of the HLA system, 2004”. Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. ↑ Hurley CK, Steiner N, Hoyer RJ; et al. (1996). “Novel HLA-B alleles, B*8201, B*3515 and B*5106, add to the complexity of serologic identification of HLA types”. Tissue Antigens. 47 (3): 179–87. PMID 8740766.
  3. ↑ Cox ST, Hossain E, McWhinnie A, Prokupek B, Madrigal JA, Little AM (2000). “HLA-B*8202 identified in a Caucasoid potential bone marrow donor”. Tissue Antigens. 56 (2): 188–91. PMID 11019925.
  4. ↑ derived from IMGT/HLA
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). “New allele frequency database: http://www.allelefrequencies.net“. Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)

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