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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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HLA-B*83

Introduction

HLA-B*83 (B83) is an HLA–B allele-group composed of a single allele, B*8301. There is no useful serology associated with this allele.[1] It is found in a single Mbenzele Pygmy tribe of the Central Africa Republic at 1.5%.[2] B*8301 appears to be the result of the replacement of exon 2 from B*4402 with exon 2 from B*5603.[3]

Location of Central African Republic
Location of Africa’s Pygmy Tribes

References

  1. ↑ Marsh SG, Albert ED, Bodmer WF; et al. (2005). “Nomenclature for factors of the HLA system, 2004”. Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. ↑ Bruges Armas J, Destro-Bisol G, López-Vazquez A; et al. (2003). “Pygmies“. Tissue Antigens. 62 (3): 233–42. PMID 12956877.
  3. ↑ Steiner NK, Gans CP, Kosman C; et al. (2001). “New alleles in the B44 family including B*44022, B*44032, B*4411, B*4420, B*4421, B*4424, and B*8301”. Tissue Antigens. 57 (4): 376–9. PMID 11380952.

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