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HLA-B53

Introduction

HLA-B53 (B53) is an HLA–B serotype. The serotype identifies the more common HLA-B*53 gene products.[1] The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion.[2] This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. ((For terminology help see: HLA-serotype tutorial)

Serotype

Serotype

B53 and B35 serotype recognition of Some HLA B*35 allele-group gene products[3]
B*53 B53 B35 Sample
allele % % size (N)
5301 86 5 3054
5302 80 20 5
B*5301 allele frequencies

B*5301 allele frequencies

HLA B*7801 frequencies
freq
ref. Population (%)
[4] Akan Adiopodoume (Ivory Coast) 22.7
[4] Rimaibe (Burkina Faso) 22.3
[4] Mossi (Burkina Faso) 20.8
[4] Bandiagara (Mali) 15.9
[4] Sawa (Cameroon) 11.5
[4] Lusaka (Zambia) 10.2
[4] Baka Pygmy (Cameroon) 10.0
[4] Guinea Bissau 10.0
[4] Harare Shona (Zimbabwe) 9.3
[4] Baloch (Iran) 9.1
[4] Kenya 8.7
[4] Canoncito Navajo (USA) 8.5
[4] Brahui (Pakistan) 7.7
[4] Niokholo Mandenka (Senegal) 5.3
[4] Croatia (2) 5.0
[4] Mongolia Khoton Tarialan 4.9
[4] Pakistan Baloch 4.6
[4] Casablanca (Morocco) 3.7
[4] Arratia Basque (Spain) 3.3
[4] Crete (Greece) 3.2
[4] Israel Arab Druse 2.5
[4] Israel Gaza Palestinians 2.4
[4] Amman (Jordan ) 2.4
[4] Tunis (Tunisia ) 2.3
[4] Tuva (2) (Russia) 2.2
[4] Oman 2.1
[4] France South East 1.6
[4] Saudi Arabia Guraiat and Hail 1.5
[4] Berber (Morocco) 1.4
[4] Georgia Svaneti Svans 1.3
[4] Mongolia Khalkh Ulaanbaatar 1.2
[4] Spain Catalonia Girona 1.1
[4] India Andhra Pradesh Golla 1.0
[4] Mongolia Khalha 1.0
Haplotype frequencies

Haplotype frequencies

A*3601 : Cw*0401 : B*5301
freq
ref. Population (%)
Zimbabwe 3.6
[4] Zambia Lusaka 2.3
N. Afr. Negroid 2.1
[4] Kenya Luo 1.9
[4] Cameroon Yaounde 1.7
[5] African American 1.5
[4] Kenya Nandi 1.3
[5] American Hispanic 0.2
‘
A*6802 : Cw*0401 : B*5301
[4] Mali Bandihagara 2.7
[5] African American 1.4
[4] Kenya Nandi 1.0
[5] Hispanic American 0.6
[5] Caucasian American 0.2

Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in african americans.

References

References

  1. ↑ Marsh SG, Albert ED, Bodmer WF; et al. (2005). “Nomenclature for factors of the HLA system, 2004”. Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. ↑ Allsopp CE, Hill AV, Kwiatkowski D; et al. (1991). “Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35”. Hum. Immunol. 30 (2): 105–9. PMID 2022493.
  3. ↑ derived from IMGT/HLA
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 4.30 4.31 4.32 4.33 4.34 4.35 4.36 4.37 4.38 4.39 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). “New allele frequency database: http://www.allelefrequencies.net“. Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)
  5. ↑ 5.0 5.1 5.2 5.3 5.4 Maiers M, Gragert L, Klitz W (2007). “High-resolution HLA alleles and haplotypes in the United States population”. Hum. Immunol. 68 (9): 779–88. doi:10.1016/j.humimm.2007.04.005. PMID 17869653.

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