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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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HLA-B67

Introduction

HLA-B67 (B67) is an HLA–B serotype. The serotype identifies the more common HLA-B*67 gene products.[1] B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim (Taiwan, Japan, Korea, Coastal Siberia), and B7, B22, or B27.[2] (For terminology help see: HLA-serotype tutorial)

Serotype

Serotype

B67 Serotype recognition of the B*67 allele-group gene products[3]
B*67 B67 Other Sample
allele % % size (N)
6701 32 62 81

By allele

Regions of higher B*6701 frequency
Japan
Taiwan
Heilongjiang
province, China
(Harbin city)
Beijing
China
Shandong
peninsula
HLA B*6701 frequencies
freq
ref. Population (%)
[4] Osaka Region (Japan) 2.6
[4] Hakka (Taiwan) 1.8
[4] Japan (5) 1.7
[4] Harbin Man (China) 1.7
[4] Beijing (China) 1.5
[4] Linqu (Shandong, China) 1.1
[4] Siraya (Taiwan) 1.0
[4] Portugal South 1.0
[4] Oold (Mongolia) 1.0
[4] American Samoa 1.0
[4] Pazeh (Taiwan) 0.9
[4] South Korea (3) 0.9
[4] N. Korean (Harbin,China) 0.8
[4] Arratia Basque (Spain) 0.6
[4] Tarialan Khoton (Mongolia) 0.6
[4] Shanghai (China) 0.6
[4] Natal Zulu (South African) 0.5
[4] Yunnan Han (China) 0.5
[4] Turkey 0.4
[4] Southern Han (China) 0.4
[4] Tuva (Russia) 0.3
[4] Chinese (Hong Kong , China) 0.1
References

References

  1. ↑ Marsh SG, Albert ED, Bodmer WF; et al. (2005). “Nomenclature for factors of the HLA system, 2004”. Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. ↑ Little AM, Domena JD, Hildebrand WH; et al. (1994). “HLA-B67: a member of the HLA-B16 family that expresses the ME1 epitope”. Tissue Antigens. 43 (1): 38–43. PMID 7517584.
  3. ↑ derived from IMGT/HLA
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). “New allele frequency database: http://www.allelefrequencies.net“. Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)

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