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Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.

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HLA-B73

Introduction

HLA-B73 (B73) is an HLA–B serotype. The serotype identifies the HLA-B*7301 gene product.[1] Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes.[2] B73 is more common in Western Indian Ocean, Mediterranean and Africa. (For terminology help see: HLA-serotype tutorial)

Serotype

Serotype

B73 serotype recognition of B*7301 allele-group gene products[3]
B*73 B73 Other Sample
allele % % size (N)
7301 22 69 106
B*7301 frequencies

B*7301 frequencies

HLA B*7301 frequencies
freq
ref. Population (%)
[4] Parsi (Karachi, Pakistan) 4.9
[4] United Arab Emirates 2.0
[4] Italy 2.0
[4] Seri (Sonora, Mexico) 1.5
[4] P’urhépecha (Michoacan, Mexico) 1.5
[4] Jews (Israel) (*2 studies) 1.2
[4] Beti (Cameroon) 1.1
[4] Casablanca (Morocco) 0.9
[4] Tbilisi (Georgia) 0.9
[4] Mossi (Burkina Faso) 0.9
[4] Bulgaria 0.9
[4] Sudanese 0.8
[4] Tuva (Russia) (2) 0.8
[4] Oman 0.8
[4] Bamileke (Cameroon) 0.6
[4] Pathan (Pakistan) 0.5
[4] Khalkha (Mongolia) 0.5
[4] Druse Arabs (Israel) 0.5
[4] Baloch (Iran) 0.5
[4] Manchester (England) 0.5
[4] Algeria (1) 0.5
[4] Turkey 0.4
[4] Amman (Jordan) 0.3
[4] Shona (Harare, Zimbabwe) 0.2
[4] Republic of Macedonia 0.2
[4] Nandi (Kenya) 0.2
[4] Luo (Kenya) 0.2
[4] Campania (Italy) 0.2
[4] Greece 0.2
References

References

  1. ↑ Marsh SG, Albert ED, Bodmer WF; et al. (2005). “Nomenclature for factors of the HLA system, 2004”. Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
  2. ↑ Hoffmann HJ, Kristensen TJ, Jensen TG, Graugaard B, Lamm LU (1995). “Antigenic characteristics and cDNA sequences of HLA-B73”. Eur. J. Immunogenet. 22 (3): 231–40. PMID 8547229.
  3. ↑ derived from IMGT/HLA
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). “New allele frequency database: http://www.allelefrequencies.net“. Tissue Antigens. 61 (5): 403–7. PMID 12753660. External link in |title= (help)

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