Halazepam

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Halazepam is a benzodiazepine derivative that was marketed under the brand names Paxipam in the United States,^[1] Alapryl in Spain,^[2] and Pacinone in Portugal.^[3]

Medical uses

Halazepam was used for the treatment of anxiety.^[1]

Adverse effects

Adverse effects include drowsiness, confusion, dizziness, and sedation. Gastrointestinal side effects have also been reported including dry mouth and nausea.^[1]

Pharmacokinetics and pharmacodynamics

Pharmacokinetics and pharmacodynamics were listed in Current Psychotherapeutic Drugs published in June 15, 1998 as follows:^[4]

Onset of action	Intermediate to slow
Plasma half life	14 hr for parent drug and 30-100 hr for its metabolite
Peak plasma levels	1-3 hr for parent drug and 3-6 hf for its metabolite
Metabolism	Metabolized into desmethyldiazepam and 3-hydroxyhalazepam (in the liver)
Excretion	Excreted through kidneys
Protein binding	98% bound to plasma protein

Regulatory Information

Halazepam is classified as a schedule 4 controlled substance with a corresponding code 2762 by the Drug Enforcement Administration (DEA).^[5]

Commercial production

Halazepam was invented by Schlesinger Walter in the U.S. It was marketed as an anti-anxiety agent in 1981. However, Halazepam is not commercially available in the United States because it was withdrawn by its manufacturer for poor sales.^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 “halazepam”. Drugs.com. Retrieved December 11, 2014.
↑ “Alapryl”. Drugs.com. Retrieved December 11, 2014.
↑ “Pacinone”. Drugs.com. Retrieved December 11, 2014.
↑ Quitkin, Frederick M. … (1998). Current therapeutic drugs (2nd ed. ed.). Washington: American Psychiatric Press. p. 166. ISBN 0880489944.CS1 maint: Extra text (link)
↑ “SCHEDULES OF CONTROLLED SUBSTANCES”. Code of Federal Reguations. 2012-04-01. pp. § 1308.14 Schedule IV. Retrieved December 12, 2014.

Template:Benzodiazepines Template:Anxiolytics

[DrugsH-1] 1.0 ^1.1 ^1.2 ^1.3 “halazepam”. Drugs.com. Retrieved December 11, 2014.

[DrugsA-2] “Alapryl”. Drugs.com. Retrieved December 11, 2014.

[DrugsP-3] “Pacinone”. Drugs.com. Retrieved December 11, 2014.

[4] Quitkin, Frederick M. … (1998). Current therapeutic drugs (2nd ed. ed.). Washington: American Psychiatric Press. p. 166. ISBN 0880489944.CS1 maint: Extra text (link)

[DEA-5] “SCHEDULES OF CONTROLLED SUBSTANCES”. Code of Federal Reguations. 2012-04-01. pp. § 1308.14 Schedule IV. Retrieved December 12, 2014.

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