Hashimoto's thyroiditis causes
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]
Overview
Overview
Hashimoto’s thyroiditis may be caused by T cells and B cells auto-activation, genetic factors, and autoimmune antibodies against thyrotropin receptors.
Causes
Causes
Hashimoto’s thyroiditis usually caused by:[1][2]
Common Causes
- Autoantibodies against thyroid peroxidase and thyroglobulin
- Abnormalities in the suppressor T cells and regulatory T cells
- HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement
Less common cause
- Immunomodulatory drugs (e.g, interferon-alpha)
- Monoclonal antibodies that block CTLA-4
- Cancer vaccines
- Micro RNA involvement
- Polyglandular Syndrome
For the factors involved in the development of Hashimoto’s thyroiditis, please click here.
References
References
- ↑ Ajjan RA, Weetman AP (2015). “The Pathogenesis of Hashimoto’s Thyroiditis: Further Developments in our Understanding”. Horm. Metab. Res. 47 (10): 702–10. doi:10.1055/s-0035-1548832. PMID 26361257.
- ↑ Caturegli P, De Remigis A, Rose NR (2014). “Hashimoto thyroiditis: clinical and diagnostic criteria”. Autoimmun Rev. 13 (4–5): 391–7. doi:10.1016/j.autrev.2014.01.007. PMID 24434360.
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