Health Dictionary
Reliable, easy-to-read patient information on common medical conditions — written in plain language, free of jargon, and grounded in current evidence. Browse the most frequent diagnoses, understand what they mean for everyday life, and learn which steps and questions help you have a focused conversation with your doctor.
Hashimoto's thyroiditis causes
Introduction
Overview
Overview
Hashimoto’s thyroiditis may be caused by T cells and B cells auto-activation, genetic factors, and autoimmune antibodies against thyrotropin receptors.
Causes
Causes
Hashimoto’s thyroiditis usually caused by:[1][2]
Common Causes
- Autoantibodies against thyroid peroxidase and thyroglobulin
- Abnormalities in the suppressor T cells and regulatory T cells
- HLA-B* 46:01, HLA-A* 02:07 and HLA-DRB4 involvement
Less common cause
- Immunomodulatory drugs (e.g, interferon-alpha)
- Monoclonal antibodies that block CTLA-4
- Cancer vaccines
- Micro RNA involvement
- Polyglandular Syndrome
For the factors involved in the development of Hashimoto’s thyroiditis, please click here.
References
References
- ↑ Ajjan RA, Weetman AP (2015). “The Pathogenesis of Hashimoto’s Thyroiditis: Further Developments in our Understanding”. Horm. Metab. Res. 47 (10): 702–10. doi:10.1055/s-0035-1548832. PMID 26361257.
- ↑ Caturegli P, De Remigis A, Rose NR (2014). “Hashimoto thyroiditis: clinical and diagnostic criteria”. Autoimmun Rev. 13 (4–5): 391–7. doi:10.1016/j.autrev.2014.01.007. PMID 24434360.
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Furqan M M. M.B.B.S[2]